Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

(2014) Shoshana M. Bartell et al.   Nature Communications

Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons

(2013) Adam J. Case et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone

(2013) Beyzagul Polat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Steap4 Plays a Critical Role in Osteoclastogenesisin Vitroby Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

(2013) Jian Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

(2013) Hiroyuki Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase II Antioxidant Enzymes

(2013) Eiko Sakai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Polyphenol Fisetin Protects Bone by Repressing NF-κB and MKP-1-Dependent Signaling Pathways in Osteoclasts

(2013) Laurent Léotoing et al.   PLoS One

β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species

(2012) Hisataka Kondo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation

(2012) Ho-Jin Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydrogen water consumption prevents osteopenia in ovariectomized rats

(2012) Ji-Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ormeloxifene inhibits osteoclast differentiation in parallel to downregulating RANKL-induced ROS generation and suppressing the activation of ERK and JNK in murine RAW264.7 cells

(2012) Geetika Kharkwal et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone

(2011) Mamiko Hie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

(2011) Ho-Jin Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

(2011) Mayumi Nomura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

(2011) Yoshiomi Oka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production

(2010) Xu He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures

(2010) Ki Hyun Baek et al.   CALCIFIED TISSUE INTERNATIONAL

Continuous Treatment with a Low-Dose β-Agonist Reduces Bone Mass by Increasing Bone Resorption Without Suppressing Bone Formation

(2010) Hisataka Kondo et al.   CALCIFIED TISSUE INTERNATIONAL

RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+Oscillations Essential for Osteoclastogenesis

(2010) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide: A cytokine-induced regulator of bone resorption

(2010) Stuart H. Ralston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nitric oxide and bone

(2010) Deborah M. Evans et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclastic superoxide production and bone resorption: Stimulation and inhibition by modulators of NADPH oxidase

(2010) Alix G. Darden et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ascorbic acid accelerates osteoclast formation and death

(2009) Damien Le Nihouannen et al.   BONE

Receptor activator of nuclear factor-κB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues

(2009) Hideyuki Sasaki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts

(2009) Myung Hee Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Nitric oxide enhances osteoclastogenesis possibly by mediating cell fusion

(2009) Dorrin Nilforoushan et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in bone remodelling and disease

(2009) Fabien Wauquier et al.   TRENDS IN MOLECULAR MEDICINE

Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-cholesterol diet

(2008) Toshihiro Sanbe et al.   ARCHIVES OF ORAL BIOLOGY

Dried Plum Polyphenols Inhibit Osteoclastogenesis by Downregulating NFATc1 and Inflammatory Mediators

(2008) So Young Bu et al.   CALCIFIED TISSUE INTERNATIONAL

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB

(2008) Tae-Wook Kyung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis

(2008) Myung Hee Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway

(2008) Kwang Seok Ahn et al.   INTERNATIONAL JOURNAL OF CANCER