Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses

Conformation space of a heterodimeric ABC exporter under turnover conditions

(2019) Susanne Hofmann et al.   NATURE

The extracellular gate shapes the energy profile of an ABC exporter

(2019) Cedric A. J. Hutter et al.   Nature Communications

Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters

(2019) Sriram Srikant et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1

(2018) Zachary Lee Johnson et al.   CELL

Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET

(2018) Florence Husada et al.   EMBO JOURNAL

Structure, Gating, and Regulation of the CFTR Anion Channel

(2018) László Csanády et al.   PHYSIOLOGICAL REVIEWS

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Dynamics of P-type ATPase transport revealed by single-molecule FRET

(2017) Mateusz Dyla et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F

(2017) Joris M. H. Goudsmits et al.   Nature Communications

Exploring conformational equilibria of a heterodimeric ABC transporter

(2017) M Hadi Timachi et al.   eLife

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale

(2016) Manuel F Juette et al.   NATURE METHODS

A single active catalytic site is sufficient to promote transport in P-glycoprotein

(2016) Orsolya Bársony et al.   Scientific Reports

Structural dynamics of potassium-channel gating revealed by single-molecule FRET

(2015) Shizhen Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural dynamics of potassium-channel gating revealed by single-molecule FRET

(2015) Shizhen Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Empirical Bayes Methods Enable Advanced Population-Level Analyses of Single-Molecule FRET Experiments

(2014) Jan-Willem van de Meent et al.   BIOPHYSICAL JOURNAL

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Multidrug Resistance Protein 1 (MRP1, ABCC1): Past, Present, and Future

(2013) Susan P.C. Cole   Annual Review of Pharmacology and Toxicology

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mitigating Unwanted Photophysical Processes for Improved Single-Molecule Fluorescence Imaging

(2009) Richa Dave et al.   BIOPHYSICAL JOURNAL

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

(2009) L. Csanady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into ABC transporter mechanism

(2008) Michael L Oldham et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An Oxygen Scavenging System for Improvement of Dye Stability in Single-Molecule Fluorescence Experiments

(2007) Colin Echeverría Aitken et al.   BIOPHYSICAL JOURNAL