Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy

The Emerging Role of Voltage-Gated Sodium Channels in Tumor Biology

(2019) Weijia Mao et al.   Frontiers in Oncology

Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer

(2019) Sylvanus Kampo et al.   Frontiers in Oncology

Ion Channels: New Actors Playing in Chemotherapeutic Resistance

(2019) Philippe Kischel et al.   Cancers

T-type Calcium Channels in Cancer

(2019) Lauren Antal et al.   Cancers

Polymalic acid chlorotoxin nanoconjugate for near-infrared fluorescence guided resection of glioblastoma multiforme

(2019) Rameshwar Patil et al.   BIOMATERIALS

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch

(2019) Zhongjie Li et al.   PEPTIDES

Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

(2019) Alja Zottel et al.   Materials

Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways

(2019) Najet Srairi-Abid et al.   CELL CALCIUM

TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer

(2019) Aurélien Haustrate et al.   CELL CALCIUM

Neuropilin-1 drives tumor-specific uptake of chlorotoxin

(2019) Sharon McGonigle et al.   Cell Communication and Signaling

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

(2019) Elizabeth Varghese et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mitochondrion as an Emerging Therapeutic Target in Cancer

(2019) Katherine G. Roth et al.   TRENDS IN MOLECULAR MEDICINE

Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy

(2018) Kyoung Ah Min et al.   ARCHIVES OF PHARMACAL RESEARCH

Scorpion Venom Peptides As A Potential Source For Human Drug Candidates

(2018) Bushra Uzair et al.   PROTEIN AND PEPTIDE LETTERS

Suppression of chloride voltage‑gated channel 3 expression increases sensitivity of human glioma U251 cells to cisplatin through lysosomal dysfunction

(2018) Yihe Zhang et al.   Oncology Letters

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Therapeutic strategies involving survivin inhibition in cancer

(2018) David Martínez‐García et al.   MEDICINAL RESEARCH REVIEWS

In Silico prediction of the molecular basis of ClTx and AaCTx interaction with matrix metalloproteinase-2 (MMP-2) to inhibit glioma cell invasion

(2016) Houcemeddine Othman et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Scorpion venoms in gastric cancer

(2016) Xiao-Ying Zhang et al.   Oncology Letters

Ion channels in the regulation of apoptosis

(2015) Artem Kondratskyi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members

(2015) Joseph T. Opferman   FEBS Journal

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis

(2015) Michaela Nelson et al.   Molecular Cancer

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

Analgesic-antitumor peptide inhibits the migration and invasion of HepG2 cells by an upregulated VGSC β1 subunit

(2015) Guili Guo et al.   TUMOR BIOLOGY

Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

(2015) Michaela Nelson et al.   Oncotarget

Cytotoxicity of Recombinant Tamapin and Related Toxin-Like Peptides on Model Cell Lines

(2014) Belén Ramírez-Cordero et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Scorpion venoms as a potential source of novel cancer therapeutic compounds

(2014) Jian Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes

(2014) Chao Qin et al.   MOLECULAR PHARMACEUTICS

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway

(2014) BRANDON M. SCHICKLING et al.   ONCOLOGY REPORTS

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

(2014) Adam Bartok et al.   TOXICON

Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study

(2014) Qingxuan Lai et al.   BMJ Open

Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer

(2013) Massimo D’Amico et al.   Recent Patents on Anti-Cancer Drug Discovery

Induction of Apoptosis by a Combination of Paclitaxel and Carboplatin in the Presence of Hyperthermia

(2012) Tao Huang et al.   Asian Pacific Journal of Cancer Prevention

Voltage-gated sodium channels and metastatic disease

(2012) William J. Brackenbury   Channels

Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells

(2012) Nora Graf et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The role of the TRPV6 channel in cancer

(2012) V’yacheslav Lehen’kyi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Global cancer transitions according to the Human Development Index (2008–2030): a population-based study

(2012) Freddie Bray et al.   LANCET ONCOLOGY

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Phase II Study of Bevacizumab in Combination with Trastuzumab and Capecitabine as First-Line Treatment for HER-2-positive Locally Recurrent or Metastatic Breast Cancer

(2012) M. Martin et al.   ONCOLOGIST

Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model

(2012) A T Robilotto et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Mitochondrial Dynamics and Apoptosis--the ER Connection

(2012) S. Hoppins et al.   SCIENCE

Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells

(2012) YU GU et al.   Oncology Letters

Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis

(2011) V'yacheslav Lehen'kyi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium and cell death mechanisms: A perspective from the cell death community

(2011) Boris Zhivotovsky et al.   CELL CALCIUM

High Expression of Transient Receptor Potential Channels in Human Breast Cancer Epithelial Cells and Tissues: Correlation with Pathological Parameters

(2011) Isabelle Dhennin-Duthille et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells

(2011) Youlong Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Blockade of Chloride Ion Transport Enhances the Cytocidal Effect of Hypotonic Solution in Gastric Cancer Cells

(2011) Daisuke Iitaka et al.   JOURNAL OF SURGICAL RESEARCH

Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom

(2011) Ilhem Rjeibi et al.   PEPTIDES

Cell Death Mechanisms Induced by Cytotoxic Lymphocytes

(2010) L Chávez-Galán et al.   Cellular & Molecular Immunology

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

(2010) Soo Hwa Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Ion channels and the hallmarks of cancer

(2010) Natalia Prevarskaya et al.   TRENDS IN MOLECULAR MEDICINE

BmKCT toxin inhibits glioma proliferation and tumor metastasis

(2009) Shaozhong Fan et al.   CANCER LETTERS

Annexin A2 Is a Molecular Target for TM601, a Peptide with Tumor-targeting and Anti-angiogenic Effects

(2009) Kamala Kesavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Inhibitor of apoptosis proteins and apoptosis

(2008) Yunbo Wei et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells

(2008) Mi-Kyung Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Potassium Channels Keep Mobile Cells on the Go

(2008) Albrecht Schwab et al.   PHYSIOLOGY

T-type Ca2+ channel expression in human esophageal carcinomas: A functional role in proliferation

(2007) Fengmin Lu et al.   CELL CALCIUM