Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism

(2020) Aarti Krishnan et al.   Cell Host & Microbe

A reusable polymer-supported copper(I) catalyst for triazole click reaction on water: An experimental and computational study

(2019) Lahoucine Bahsis et al.   APPLIED ORGANOMETALLIC CHEMISTRY

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

(2019) L. Brock Thornton et al.   PLoS Pathogens

Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis

(2019) Edwin T. Tjhin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Facile Synthesis of Sequence-Regulated Synthetic Polymers Using Orthogonal SuFEx and CuAAC Click Reactions

(2018) Cangjie Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plasmodium heme biosynthesis: To be or not to be essential?

(2017) Daniel E. Goldberg et al.   PLoS Pathogens

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Regulation of intracellular heme trafficking revealed by subcellular reporters

(2016) Xiaojing Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

(2016) David A. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetically Encoded FRET Sensor for Intracellular Heme

(2015) Yanqun Song et al.   ACS Chemical Biology

Lytic Cycle of Toxoplasma gondii: 15 Years Later

(2015) Ira J. Blader et al.   Annual Review of Microbiology

Deconvoluting heme biosynthesis to target blood-stage malaria parasites

(2015) Paul A Sigala et al.   eLife

The Heme Biosynthesis Pathway Is Essential forPlasmodium falciparumDevelopment in Mosquito Stage but Not in Blood Stages

(2014) Hangjun Ke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

Make It, Take It, or Leave It: Heme Metabolism of Parasites

(2013) Luděk Kořený et al.   PLoS Pathogens

Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection

(2013) Viswanathan Arun Nagaraj et al.   PLoS Pathogens

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

The Use and Abuse of Heme in Apicomplexan Parasites

(2012) Giel G. van Dooren et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1

(2012) Chau Huynh et al.   PLoS Pathogens

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) “click” reaction and its applications. An overview

(2011) Liyuan Liang et al.   COORDINATION CHEMISTRY REVIEWS

Crystal Structure ofToxoplasma gondiiPorphobilinogen Synthase

(2011) Eileen K. Jaffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

(2011) Luděk Kořený et al.   PLANT CELL

A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor

(2011) Lilach Sheiner et al.   PLoS Pathogens

Plastid-associated Porphobilinogen Synthase fromToxoplasma gondii

(2010) Dhanasekaran Shanmugam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tagging of Endogenous Genes in aToxoplasma gondiiStrain Lacking Ku80

(2009) My-Hang Huynh et al.   EUKARYOTIC CELL

Uroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymes

(2008) C. A. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA