Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis
Authors
Keywords
-
Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-04-15
DOI
10.1038/s41598-020-63254-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease
- (2018) Bobby Ranjan et al. BMC Systems Biology
- Calcium signaling and molecular mechanisms underlying neurodegenerative diseases
- (2018) Ekaterina Pchitskaya et al. CELL CALCIUM
- Phenotypic Profile of Early-Onset Familial Alzheimer's Disease Caused by Presenilin-1 E280A Mutation
- (2018) Diego Sepulveda-Falla et al. JOURNAL OF ALZHEIMERS DISEASE
- Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
- (2017) Sabrina Contino et al. Frontiers in Physiology
- Molecular genetics of early-onset Alzheimer's disease revisited
- (2016) Rita Cacace et al. Alzheimers & Dementia
- The Cellular Phase of Alzheimer’s Disease
- (2016) Bart De Strooper et al. CELL
- The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore
- (2016) Patrick Toglia et al. CELL CALCIUM
- Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
- (2016) Stephen P. Duggan et al. CELLULAR SIGNALLING
- Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques
- (2016) Massimo Bonora et al. Nature Protocols
- Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling
- (2015) Joachim Krebs et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively
- (2015) Linlin Zeng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
- (2015) Maria Szaruga et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease
- (2015) Chris Cadonic et al. MOLECULAR NEUROBIOLOGY
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime
- (2015) MaryKate McBrayer et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis
- (2014) Michela Guglielmotto et al. Autophagy
- Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
- (2014) Bumsup Kwon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Novel insights into the mitochondrial permeability transition
- (2014) Massimo Bonora et al. CELL CYCLE
- Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis
- (2014) Diego Sepulveda-Falla et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes
- (2013) Massimo Bonora et al. Nature Protocols
- The E280A Presenilin Mutation Reduces Voltage-Gated Sodium Channel Levels in Neuronal Cells
- (2013) Doo Yeon Kim et al. Neurodegenerative Diseases
- The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells
- (2013) Grace Woodruff et al. Cell Reports
- Biological function of Presenilin and its role in AD pathogenesis
- (2013) Shuting Zhang et al. Translational Neurodegeneration
- Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease
- (2012) Lyndsay Murrow et al. Annual Review of Pathology-Mechanisms of Disease
- Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
- (2012) D. Allan Butterfield et al. ANTIOXIDANTS & REDOX SIGNALING
- Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
- (2012) Estela Area-Gomez et al. EMBO JOURNAL
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Presenilins: Role in calcium homeostasis
- (2012) Kamran Honarnejad et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Presenilins: A novel link between intracellular calcium signaling and lysosomal function?: Figure 1.
- (2012) Ilya Bezprozvanny JOURNAL OF CELL BIOLOGY
- Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors
- (2012) M-L Wong et al. MOLECULAR PSYCHIATRY
- Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress
- (2011) Anna G. Barsukova et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo
- (2011) Tomohiro Umeda et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins
- (2011) Claudia Manzoni et al. PLoS One
- Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
- (2011) E. Zampese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlating familial Alzheimer’s disease gene mutations with clinical phenotype
- (2010) Natalie S Ryan et al. Biomarkers in Medicine
- Role of Presenilins in Neuronal Calcium Homeostasis
- (2010) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis
- (2010) S. W. Pimplikar et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice
- (2010) Mary Wines-Samuelson et al. PLoS One
- Mitochondria, calcium and cell death: A deadly triad in neurodegeneration
- (2009) Fulvio Celsi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta
- (2009) Heng Du et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Exposure of any of two proapoptotic domains of presenilin 1-associated protein/mitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a Bax/Bak-independent manner
- (2008) V LAMARCA et al. EUROPEAN JOURNAL OF CELL BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started