Serelaxin activates eNOS, suppresses inflammation, attenuates developmental delay and improves cognitive functions of neonatal rats after germinal matrix hemorrhage

Efficacy and safety of serelaxin when added to standard of care in patients with acute heart failure: results from a PROBE study, RELAX-AHF-EU

(2019) Aldo P. Maggioni et al.   EUROPEAN JOURNAL OF HEART FAILURE

Rh-IFN-α attenuates neuroinflammation and improves neurological function by inhibiting NF-κB through JAK1-STAT1/TRAF3 pathway in an experimental GMH rat model

(2019) Peng Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Association of Circulating Proinflammatory and Anti-inflammatory Protein Biomarkers in Extremely Preterm Born Children with Subsequent Brain Magnetic Resonance Imaging Volumes and Cognitive Function at Age 10 Years

(2019) Karl C.K. Kuban et al.   JOURNAL OF PEDIATRICS

Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability by improvement of eNOS uncoupling and activation eNOS/NO

(2019) Song Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

T-Regulatory Cells Confer Increased Myelination and Stem Cell Activity after Stroke-Induced White Matter Injury

(2019) Sydney Zarriello et al.   Journal of Clinical Medicine

Selective head cooling and whole body cooling as neuroprotective agents in severe perinatal asphyxia

(2019) Mahara Nonato et al.   Revista da Associacao Medica Brasileira

Modified behavioural tests to detect white matter injury- induced motor deficits after intracerebral haemorrhage in mice

(2019) Weixiang Chen et al.   Scientific Reports

Short-Term Acute Exercise Preconditioning Reduces Neurovascular Injury After Stroke Through Induced eNOS Activation

(2019) Sherif Hafez et al.   Translational Stroke Research

Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats

(2018) Yixin Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered white matter development in children born very preterm

(2018) Julia M. Young et al.   Brain Structure & Function

Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway

(2018) Yiting Zhang et al.   Journal of Neuroinflammation

Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model

(2018) Yiting Zhang et al.   NEUROBIOLOGY OF DISEASE

Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAGn51trunc Model of Huntington Disease

(2018) Anne-Christine Plank et al.   Frontiers in Neuroscience

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

(2018) Xiaoming Lian et al.   Frontiers in Physiology

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy

(2018) Beverly Giam et al.   EXPERIMENTAL PHYSIOLOGY

Serelaxin in addition to standard therapy in acute heart failure: rationale and design of the RELAX-AHF-2 study

(2017) John R. Teerlink et al.   EUROPEAN JOURNAL OF HEART FAILURE

Early Anti-inflammatory and Pro-angiogenic Myocardial Effects of Intravenous Serelaxin Infusion for 72 H in an Experimental Rat Model of Acute Myocardial Infarction

(2017) Jesus Sanchez-Mas et al.   Journal of Cardiovascular Translational Research

Role of endothelial nitric oxide synthase and endothelin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants

(2017) Dawid Szpecht et al.   Scientific Reports

Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats

(2017) Dong Wang et al.   Scientific Reports

Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)

(2016) C H Leo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serelaxin in acute heart failure: Most recent update on clinical and preclinical evidence

(2016) Raktim Kumar Ghosh et al.   Cardiovascular Therapeutics

Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups

(2016) Damon Klebe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage

(2016) P. Dohare et al.   JOURNAL OF NEUROSCIENCE

Intraventricular Hemorrhage and Platelet Indices in Extremely Premature Neonates

(2016) Georgios Mitsiakos et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

A Century of Germinal Matrix Intraventricular Hemorrhage in Autopsied Premature Infants: A Historical Account

(2016) Marco M. Hefti et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Serelaxin (recombinant human relaxin-2) prevents high glucose-induced endothelial dysfunction by ameliorating prostacyclin production in the mouse aorta

(2016) Hooi Hooi Ng et al.   PHARMACOLOGICAL RESEARCH

Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage

(2016) Pei-Yi Lin et al.   Scientific Reports

Pharmacokinetics of serelaxin in patients with hepatic impairment: a single-dose, open-label, parallel group study

(2015) Zhanna Kobalava et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Relaxin Peptide Hormones Are Protective During the Early Stages of Ischemic Stroke in Male Rats

(2015) Lindsay H. Bergeron et al.   ENDOCRINOLOGY

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populat

(2015) Marion Dahlke et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of outcome methods assessing short- and long-term outcome after therapeutic hypothermia

(2015) Hemmen Sabir et al.   Seminars in Fetal & Neonatal Medicine

Combined Treatment of Xenon and Hypothermia in Newborn Rats - Additive or Synergistic Effect?

(2014) Hemmen Sabir et al.   PLoS One

Inhibition of Transforming Growth Factor-β Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage

(2014) Anatol Manaenko et al.   STROKE

Relaxin Family Peptides and Their Receptors

(2013) R. A. D. Bathgate et al.   PHYSIOLOGICAL REVIEWS

Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus

(2012) Tim Lekic et al.   EXPERIMENTAL NEUROLOGY

Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage

(2012) William B. Rolland et al.   EXPERIMENTAL NEUROLOGY

Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage

(2012) Tim Lekic et al.   JOURNAL OF NEUROSURGERY

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Mechanisms of Hydrocephalus After Neonatal and Adult Intraventricular Hemorrhage

(2012) Jennifer Strahle et al.   Translational Stroke Research

Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration

(2011) Silvia Nistri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Examination of relaxin and its receptors expression in pig gametes and embryos

(2011) Jean M Feugang et al.   Reproductive Biology and Endocrinology

Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats

(2010) Nancy Fathali et al.   INTENSIVE CARE MEDICINE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Milk-Borne Relaxin and the Lactocrine Hypothesis for Maternal Programming of Neonatal Tissues

(2009) Carol A. Bagnell et al.   Annals of the New York Academy of Sciences

Glibenclamide improves neurological function in neonatal hypoxia–ischemia in rats

(2009) Yilin Zhou et al.   BRAIN RESEARCH

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Relaxin, a pleiotropic vasodilator for the treatment of heart failure

(2008) Sam L. Teichman et al.   HEART FAILURE REVIEWS

Development of Amplitude-Integrated Electroencephalography and Interburst Interval in the Rat

(2008) Alexander M Tucker et al.   PEDIATRIC RESEARCH