Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)

Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice

(2015) Hooi H. Ng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

(2014) M Sarwar et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Vasoactive Role for Endogenous Relaxin in Mesenteric Arteries of Male Mice

(2014) Chen Huei Leo et al.   PLoS One

Acute Intravenous Injection of Serelaxin (Recombinant Human Relaxin‐2) Causes Rapid and Sustained Bradykinin‐Mediated Vasorelaxation

(2014) Chen Huei Leo et al.   Journal of the American Heart Association

A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure

(2013) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

(2013) Maria Jelinic et al.   FASEB JOURNAL

Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury

(2013) Massimo Collino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Impaired effect of relaxin on vasoconstrictor reactivity in spontaneous hypertensive rats

(2013) Joris van Drongelen et al.   PEPTIDES

Arginase II inhibition prevents nitrate tolerance

(2012) SML Khong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Relaxin improves TNF-α-induced endothelial dysfunction: the role of glucocorticoid receptor and phosphatidylinositol 3-kinase signalling

(2012) Thomas Dschietzig et al.   CARDIOVASCULAR RESEARCH

Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow

(2012) Lenka A. Vodstrcil et al.   FASEB JOURNAL

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta

(2012) C.H. Leo et al.   PHARMACOLOGICAL RESEARCH

Aging attenuates the vasodilator response to relaxin

(2011) Joris van Drongelen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitrate Therapy

(2011) Thomas Münzel et al.   CIRCULATION

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide

(2011) Jonathan T. McGuane et al.   ENDOCRINOLOGY

3′,4′-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes

(2011) Chen-Huei Leo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiogenic Growth Factors Are New and Essential Players in the Sustained Relaxin Vasodilatory Pathway in Rodents and Humans

(2011) Jonathan T. McGuane et al.   HYPERTENSION

Impaired vascular responses to relaxin in diet-induced overweight female rats

(2011) Joris van Drongelen et al.   JOURNAL OF APPLIED PHYSIOLOGY

3′,4′-Dihydroxyflavonol Reduces Superoxide and Improves Nitric Oxide Function in Diabetic Rat Mesenteric Arteries

(2011) Chen-Huei Leo et al.   PLoS One

Impairment of both nitric oxide-mediated and EDHF-type relaxation in small mesenteric arteries from rats with streptozotocin-induced diabetes

(2010) CH Leo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

(2009) Gabrielle E. Callander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY