Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology

(2019) S. F. Pedersen et al.   PHYSIOLOGICAL REVIEWS

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

(2019) Ann Lin et al.   Science Translational Medicine

3D multicellular models to study the regulation and roles of acid–base transporters in breast cancer

(2019) Dominika Czaplinska et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer

(2018) Feng Shan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms

(2018) Anne Poder Andersen et al.   INTERNATIONAL JOURNAL OF CANCER

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

(2018) Benjamin J. Buckley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

(2017) Katharine A. White et al.   JOURNAL OF CELL SCIENCE

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study

(2017) Ryan J. Sullivan et al.   Cancer Discovery

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

(2017) Ann Lin et al.   eLife

CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy

(2017) Yan Lei et al.   PLoS One

Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage

(2016) Francesca Aredia et al.   BMC CANCER

Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells

(2016) Ashley R. Rowson-Hodel et al.   CANCER LETTERS

Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment

(2016) Anne Poder Andersen et al.   Molecular Cancer

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors

(2016) Cristina Saura et al.   Cancer Discovery

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

(2016) Sofia Avnet et al.   Oncotarget

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

(2015) Schammim Ray Amith et al.   Oncotarget

Constitutively Active ErbB2 Regulates Cisplatin-Induced Cell Death in Breast Cancer Cells via Pro- and Antiapoptotic Mechanisms

(2014) Haraldur H. Sigurðsson et al.   MOLECULAR CANCER RESEARCH

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

The Intracellular Na+/H+ Exchanger NHE7 Effects a Na+-Coupled, but Not K+-Coupled Proton-Loading Mechanism in Endocytosis

(2014) Nina Milosavljevic et al.   Cell Reports

Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

(2012) Mi Jin Yoon et al.   CANCER LETTERS

Fluorescence properties of the Na+/H+exchanger inhibitor HMA (5-(N,N-hexamethylene)amiloride) are modulated by intracellular pH

(2012) V. Giansanti et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

(2011) Johanna Chiche et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Na+/H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility

(2010) Xuekang Yang et al.   CANCER LETTERS

NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

(2010) G. Lauritzen et al.   EXPERIMENTAL CELL RESEARCH

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Amiloride derivatives induce apoptosis by depleting ER Ca2+ stores in vascular endothelial cells

(2009) KS Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols