Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles

Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole

(2012) Harunobu Mitsunuma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

An Easy Entry to Optically Active Spiroindolinones: Chiral Brønsted Acid-Catalysed Pictet-Spengler Reactions of Isatins

(2011) Sara Duce et al.   ADVANCED SYNTHESIS & CATALYSIS

The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious

(2011) Grzegorz M. Popowicz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines

(2011) Gang Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dioxindole in Asymmetric Catalytic Synthesis: Routes to Enantioenriched 3-Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A

(2011) Giulia Bergonzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines

(2011) Xiaohong Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Ring-Opening ofmeso-Aziridines with Malonates under Heterodinuclear Rare Earth Metal Schiff Base Catalysis

(2011) Yingjie Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclicortho-Quinodimethanes

(2011) Yankai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Tertiary Amine-Catalyzed Chemoselective and Asymmetric [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates of Isatins with Propargyl Sulfones

(2011) Jing Peng et al.   ORGANIC LETTERS

Optimization of the Central Core of Indolinone–Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists

(2011) Stefano Crosignani et al.   ACS Medicinal Chemistry Letters

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

(2010) Viktor V. Vintonyak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists

(2010) Anna Czarna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dinuclear Ni2–Schiff base complex-catalyzed asymmetric 1,4-addition of β-keto esters to nitroethylene toward γ2,2-amino acid synthesis

(2010) Harunobu Mitsunuma et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Catalytic Asymmetric Vinylogous Mannich-Type and Michael Reactions of an α,β-Unsaturated γ-Butyrolactam under Dinuclear Nickel Catalysis

(2010) Nicholas E. Shepherd et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Synthesis of 3-Aminooxindoles: Enantiofacial Selectivity Switch in Bimetallic vs Monometallic Schiff Base Catalysis

(2010) Shinsuke Mouri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Organocatalytic Asymmetric Synthesis of Protected α,β-Diamino Acids

(2009) Zugui Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-β-lactam core of chartellines

(2009) Shigeki Sato et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Synthesis of α,β-Diamino Acid Derivatives

(2009) Le Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones

(2009) Tatsuhiko Yoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Heterobimetallic Ga/Yb-Schiff Base Complex for Catalytic Asymmetric α-Addition of Isocyanides to Aldehydes

(2009) Hisashi Mihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Homodinuclear Mn(III)2−Schiff Base Complex for Catalytic Asymmetric 1,4-Additions of Oxindoles to Nitroalkenes

(2009) Yuko Kato et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Enantioselective Synthesis of Spirocyclic Benzopyranones by Rhodium‐Catalyzed Intermolecular [4+2] Annulation

(2008) Daiki Hojo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes

(2008) Xu Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient C2 functionalisation of 2H-2-imidazolines

(2007) Robin S. Bon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY