Epigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation

Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin

(2020) Yingjie Huang et al.   INFLAMMATION

Innate immunity in diabetic kidney disease

(2020) Sydney C. W. Tang et al.   Nature Reviews Nephrology

Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance

(2020) Fayyaz Ahmed et al.   PHYTOMEDICINE

Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: an update of the current state of knowledge

(2020) Sabrina Bimonte et al.   Infectious Agents and Cancer

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

(2019) Xiaohan Ning et al.   MOLECULAR CELL

Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy

(2019) Qiang Zhang et al.   CANCER RESEARCH

The role of bioactives in energy metabolism and metabolic syndrome

(2019) A. Bordoni et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Anti-osteoclastogenic effect of epigallocatechin gallate-functionalized gold nanoparticles in vitro and in vivo

(2019) Shenting Zhu et al.   International Journal of Nanomedicine

Angiopoietin-like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration

(2019) Zhiwei Liao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

(2019) Zehan Tang et al.   Cell Death & Disease

The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration

(2019) Yan Wu et al.   Clinical Interventions in Aging

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

(2019) Priya Hari et al.   Science Advances

Genomic instability and innate immune responses to self-DNA in progeria

(2019) Susana Gonzalo et al.   GeroScience

Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors

(2019) Leslie Frapin et al.   ADVANCED DRUG DELIVERY REVIEWS

Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation

(2019) Anqi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

(2019) Sidong Yang et al.   AGEING RESEARCH REVIEWS

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases

(2018) Lutz Hamann et al.   GERONTOLOGY

Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2–NF-κB p65 pathway

(2018) Yucheng Jiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Innate immunosensing of DNA in cellular senescence

(2018) Selene Glück et al.   CURRENT OPINION IN IMMUNOLOGY

Correlations BetweenCOL2AandAggrecanGenetic Polymorphisms and the Risk and Clinicopathological Features of Intervertebral Disc Degeneration in a Chinese Han Population: A Case–Control Study

(2017) Yu Deng et al.   Genetic Testing and Molecular Biomarkers

Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells

(2017) Yu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brucella abortusTriggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation

(2017) Miriam M. Costa Franco et al.   JOURNAL OF IMMUNOLOGY

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

(2017) Vidhu Mathur et al.   NEURON

The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

(2017) Pei Li et al.   Scientific Reports

TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

(2016) Yunfei Qin et al.   CELL RESEARCH

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress

(2016) Olga Krupkova et al.   Oxidative Medicine and Cellular Longevity

Effect of curcumin on aging retinal pigment epithelial cells

(2015) Jiong Lu et al.   Drug Design Development and Therapy

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology