The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

Inflammatory cytokines induce caveolin-1/β-catenin signalling in rat nucleus pulposus cell apoptosis through the p38 MAPK pathway

(2016) Jianxi Wang et al.   CELL PROLIFERATION

MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD

(2015) Tao Wang et al.   BIOCHIMIE

Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways

(2015) Qingyun Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepatocyte growth factor/c-met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro

(2015) Hidenobu Ishibashi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus

(2015) Haifeng Chen et al.   Arthritis & Rheumatology

Relationship between Initial Telomere Length, Initial Telomerase Activity, Age, and Replicative Capacity of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs: What Is a Predictor of Replicative Potential?

(2015) Jun-Seok Lee et al.   PLoS One

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Increased IL-17 expression in degenerated human discs and increased production in cultured annulus cells exposed to IL-1ß and TNF-α

(2013) HE Gruber et al.   BIOTECHNIC & HISTOCHEMISTRY

Normal and degenerated rabbit nucleus pulposus cells in in vitro cultures: A biological comparison

(2013) Bin He et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway

(2013) Jing Tian et al.   RHEUMATOLOGY INTERNATIONAL

In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes

(2013) Seo-Won Jeong et al.   Spine Journal

Silencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-κB p65

(2012) Kuiran Liu et al.   BIOSCIENCE REPORTS

Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts

(2011) Victoria Clérigues et al.   BIOCHEMICAL PHARMACOLOGY

Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage–subchondral bone explants from osteoarthritic patients

(2011) Victoria Clérigues et al.   CLINICAL SCIENCE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-α via the p38 mitogen-activated protein kinase pathway

(2009) Yanmin Zhang et al.   FASEB JOURNAL

The intervertebral disc: From pathophysiology to tissue engineering

(2009) Johann Clouet et al.   JOINT BONE SPINE

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

(2009) Ki-Won Kim et al.   Spine Journal

The matricellular functions of small leucine-rich proteoglycans (SLRPs)

(2009) Rosetta Merline et al.   Journal of Cell Communication and Signaling

Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis

(2007) Aiqun Wei et al.   Spine Journal