Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
Published 2020 View Full Article
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Title
Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
Authors
Keywords
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Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-06-01
DOI
10.1038/s41467-020-16455-7
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- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
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- (2017) Nathan C. Manley et al. Stem Cells Translational Medicine
- Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives
- (2017) Go Itakura et al. Stem Cell Reports
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- (2016) Kyle M. Loh et al. CELL
- Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells
- (2016) Shugo Tohyama et al. Cell Metabolism
- Preventing Pluripotent Cell Teratoma in Regenerative Medicine Applied to Hematology Disorders
- (2016) Aurelie Bedel et al. Stem Cells Translational Medicine
- Cloning and variation of ground state intestinal stem cells
- (2015) Xia Wang et al. NATURE
- Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
- (2015) Ayal Hendel et al. NATURE BIOTECHNOLOGY
- Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells
- (2015) Maria Rostovskaya et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition
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- (2015) Miki Ando et al. Stem Cell Reports
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- (2014) Yasuhiro Takashima et al. CELL
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- (2014) Kyle M. Loh et al. Cell Stem Cell
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- Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
- (2013) Asif M. Maroof et al. Cell Stem Cell
- FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
- (2013) Edda Spiekerkoetter et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
- (2013) Andrew S Lee et al. NATURE MEDICINE
- Inhibition of pluripotent stem cell-derived teratoma formation by small molecules
- (2013) M.-O. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells
- (2012) Zheng Wang et al. Cell Stem Cell
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- Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice
- (2012) A. Rezania et al. DIABETES
- Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment
- (2012) Yosif M. Ganat et al. JOURNAL OF CLINICAL INVESTIGATION
- Control of ground-state pluripotency by allelic regulation of Nanog
- (2012) Yusuke Miyanari et al. NATURE
- Effects of cell number on teratoma formation by human embryonic stem cells
- (2011) Andrew S. Lee et al. CELL CYCLE
- A Precarious Balance: Pluripotency Factors as Lineage Specifiers
- (2011) Kyle M. Loh et al. Cell Stem Cell
- Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
- (2011) NATURE BIOTECHNOLOGY
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- (2011) Antonio Di Stasi et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) Tamra E Werbowetski-Ogilvie et al. NATURE BIOTECHNOLOGY
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