Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

A map of the subcellular distribution of phosphoinositides in the erythrocytic cycle of the malaria parasite Plasmodium falciparum

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Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

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Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

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Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

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A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

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Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

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Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

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Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast

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Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

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Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

(2016) Nicholas J. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

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Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

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Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

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Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

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Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

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Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

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KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

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Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

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STRING v10: protein–protein interaction networks, integrated over the tree of life

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Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP

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Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions duringPlasmodium falciparumintraerythrocytic development

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Targeting Plasmodium PI(4)K to eliminate malaria

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Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme

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Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS

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Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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Role of Plasmepsin V in Export of Diverse Protein Families from thePlasmodium falciparumExportome

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Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum

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Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

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A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

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Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

(2012) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

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Genetic Analysis of Mps3 SUN Domain Mutants in Saccharomyces cerevisiae Reveals an Interaction with the SUN-Like Protein Slp1

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Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

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A new world malaria map: Plasmodium falciparum endemicity in 2010

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Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

(2011) Yo Suzuki et al.   NATURE METHODS

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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An aspartyl protease directs malaria effector proteins to the host cell

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

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Fast and accurate short read alignment with Burrows-Wheeler transform

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The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans

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Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

(2009) José B Sáenz et al.   Nature Chemical Biology

Artemisinin Resistance inPlasmodium falciparumMalaria

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Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

(2008) Alexander G. Maier et al.   CELL

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA