Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

(2018) Annie N. Cowell et al.   SCIENCE

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

(2018) Alison Roth et al.   Nature Communications

Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

(2018) Madeline R. Luth et al.   ACS Infectious Diseases

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

(2017) Benjamin Mordmüller et al.   NATURE

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

(2017) Benjamin Blasco et al.   NATURE MEDICINE

Malaria

(2017) Margaret A. Phillips et al.   Nature Reviews Disease Primers

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

(2016) Erik L. Allman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

(2016) Nobutaka Kato et al.   NATURE

A broad analysis of resistance development in the malaria parasite

(2016) Victoria C. Corey et al.   Nature Communications

The promise and pitfalls of long-acting injectable agents for HIV prevention

(2016) Raphael J. Landovitz et al.   Current Opinion in HIV and AIDS

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

(2016) Justine Swann et al.   ACS Infectious Diseases

Efficacy and safety of intermittent preventive treatment for malaria in schoolchildren: a systematic review

(2015) Junior R. Matangila et al.   MALARIA JOURNAL

The suitability of laboratory-bred Anopheles cracens for the production of Plasmodium vivax sporozoites

(2015) Chiara Andolina et al.   MALARIA JOURNAL

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

Enhancing longevity of Plasmodium vivax and P. falciparum sporozoites after dissection from mosquito salivary glands

(2015) Emily J. Lupton et al.   PARASITOLOGY INTERNATIONAL

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Designing malaria vaccines to circumvent antigen variability

(2015) Amed Ouattara et al.   VACCINE

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

(2014) Kelli L. Kuhen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of pathogen genomic variants through an integrated pipeline

(2014) Micah J Manary et al.   BMC BIOINFORMATICS

In VitroResistance Selections forPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

(2014) Leila S. Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

(2014) Xiaoyi Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

(2014) Dominic Birth et al.   Nature Communications

supraHex: An R/Bioconductor package for tabular omics data analysis using a supra-hexagonal map

(2013) Hai Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Using Genetic Methods To Define the Targets of Compounds with Antimalarial Activity

(2013) Erika L. Flannery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

A Chemical Genomic Analysis of Decoquinate, aPlasmodium falciparumCytochromebInhibitor

(2011) Tae-gyu Nam et al.   ACS Chemical Biology

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

(2010) Bryan K. S. Yeung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Analysis of Flavin Oxidation and Electron-Transfer Inhibition inPlasmodium falciparumDihydroorotate Dehydrogenase†

(2008) Nicholas A. Malmquist et al.   BIOCHEMISTRY

Identification and Characterization of Small Molecule Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase

(2008) Vishal Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte Permissiveness to Plasmodium Infection Is Conveyed by a Short and Structurally Conserved Region of the CD81 Large Extracellular Domain

(2008) Samir Yalaoui et al.   PLoS Pathogens