Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway

(2012) Duk-Won D. Chung et al.   PLoS One

PK4, a eukaryotic initiation factor 2 (eIF2 ) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

(2012) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion

(2012) Danushka S. Marapana et al.   TRAFFIC

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

The Threat of Artemisinin-Resistant Malaria

(2011) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response

(2011) Sara J. C. Gosline et al.   PLoS One

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes

(2010) Bianca Schrul et al.   BIOCHEMICAL JOURNAL

Protein dislocation from the ER

(2010) Katrin Bagola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Heat Shock Protein 90 as a Drug Target against Protozoan Infections

(2010) Rani Pallavi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

(2009) Xuerong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

(2009) Seong-Ok Lee et al.   EMBO JOURNAL

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

(2009) A. Nzila et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

(2009) Clare Fennell et al.   MALARIA JOURNAL

Malaria parasite proteins that remodel the host erythrocyte

(2009) Alexander G. Maier et al.   NATURE REVIEWS MICROBIOLOGY

Inhibition and modulation of γ-secretase for Alzheimer’s disease

(2008) Michael S. Wolfe   Neurotherapeutics