ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells

(2019) Na Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension

(2019) Anna Ulrich et al.   EUROPEAN RESPIRATORY JOURNAL

Growth Differentiation Factor 11 Promotes Abnormal Proliferation and Angiogenesis of Pulmonary Artery Endothelial CellsNovelty and Significance

(2018) Xiufeng Yu et al.   HYPERTENSION

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

(2018) Stefan Gräf et al.   Nature Communications

Sotatercept with long-term extension for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes: a phase 2, dose-ranging trial

(2018) Rami Komrokji et al.   Lancet Haematology

Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension

(2018) Tatiana Kudryashova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension

(2018) Ivana Nikolic et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size

(2017) Od BAYARSAIKHAN et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Activin A more prominently regulates muscle mass in primates than does GDF8

(2017) Esther Latres et al.   Nature Communications

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

(2016) Robert Szulcek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

(2016) Lai-Ming Yung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevated levels of plasma transforming growth factor-β1 in idiopathic and heritable pulmonary arterial hypertension

(2016) Yi Yan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension: a case report

(2016) Guoliang Wang et al.   BMC Pulmonary Medicine

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

(2015) Oddrun Elise Olsen et al.   Cell Communication and Signaling

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Sotatercept in patients with osteolytic lesions of multiple myeloma

(2014) Kudrat M. Abdulkadyrov et al.   BRITISH JOURNAL OF HAEMATOLOGY

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

(2013) Marius M. Hoeper et al.   CIRCULATION

Transforming Growth Factor-β Signaling Promotes Pulmonary Hypertension Caused by Schistosoma Mansoni

(2013) Brian B. Graham et al.   CIRCULATION

Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women

(2013) Matthew L. Sherman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Genetics and Genomics of Pulmonary Arterial Hypertension

(2013) Florent Soubrier et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human Primary Lung Endothelial Cells in Culture

(2012) Suzy A. A. Comhair et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Evaluation of Long-term Survival From Time of Diagnosis in Pulmonary Arterial Hypertension From the REVEAL Registry

(2012) Raymond L. Benza et al.   CHEST

Interference with Myostatin/ActRIIB Signaling as a Therapeutic Strategy for Duchenne Muscular Dystrophy

(2012) Helge Amthor et al.   CURRENT GENE THERAPY

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target

(2011) C. J. Rhodes et al.   EUROPEAN RESPIRATORY JOURNAL

Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse

(2011) C. George Carlson et al.   MUSCLE & NERVE

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Redundancy of myostatin and growth/differentiation factor 11 function

(2009) Alexandra C McPherron et al.   BMC DEVELOPMENTAL BIOLOGY

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

Elevated levels of activin A in clinical and experimental pulmonary hypertension

(2009) Arne Yndestad et al.   JOURNAL OF APPLIED PHYSIOLOGY

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

(2008) Matthew Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension

(2008) Ari L. Zaiman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

(2008) R. S. Pearsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA