A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension

(2015) Xiao-bing Wang et al.   LIFE SCIENCES

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Relaxin Augments BMP-2-Induced Osteoblast Differentiation and Bone Formation

(2014) Jung-Sun Moon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta

(2014) Ingo Grafe et al.   NATURE MEDICINE

Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension

(2014) Benoît Gore et al.   PLoS One

Transforming Growth Factor-β Signaling Promotes Pulmonary Hypertension Caused by Schistosoma Mansoni

(2013) Brian B. Graham et al.   CIRCULATION

Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

(2013) Elena M. Gallo et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

(2013) Hong Ling et al.   PLoS One

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming Growth Factor-β Inhibition and Endothelin Receptor Blockade in Rats with Monocrotaline-Induced Pulmonary Hypertension

(2012) Aikaterini J. Megalou et al.   Pulmonary Circulation

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β regulates sclerostin expression via the ECR5 enhancer

(2011) Gabriela G. Loots et al.   BONE

BMP-2 and TGFβ2 Shared Pathways Regulate Endocardial Cell Transformation

(2011) Todd A. Townsend et al.   CELLS TISSUES ORGANS

Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC

(2011) Todd A. Townsend et al.   CELLULAR SIGNALLING

Transforming growth factor Beta2 is required for valve remodeling during heart development

(2011) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

(2010) Elaine Soon et al.   CIRCULATION

Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells

(2010) Jeong-Ah Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Thyroid Transcription Factor-1 Inhibits Transforming Growth Factor- -Mediated Epithelial-to-Mesenchymal Transition in Lung Adenocarcinoma Cells

(2009) R.-A. Saito et al.   CANCER RESEARCH

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

Growth-Differentiation Factor-15 for Long-Term Risk Prediction in Patients Stabilized After an Episode of Non–ST-Segment–Elevation Acute Coronary Syndrome

(2009) Kai M. Eggers et al.   Circulation-Cardiovascular Genetics

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

(2009) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension

(2009) N. Selimovic et al.   EUROPEAN RESPIRATORY JOURNAL

Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

(2008) Matthew Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension

(2008) Ari L. Zaiman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Synergistic heterozygosity for TGFβ1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension

(2008) John A Phillips et al.   GENETICS IN MEDICINE

Snail is required for TGF -induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

(2008) T. Kokudo et al.   JOURNAL OF CELL SCIENCE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL