Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

The role of endoplasmic reticulum stress in neurodegenerative disease

(2016) Chunchen Xiang et al.   APOPTOSIS

Heat shock proteins as potential targets for protective strategies in neurodegeneration

(2016) Harm H Kampinga et al.   LANCET NEUROLOGY

Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease

(2016) Christiane Möller et al.   NEUROBIOLOGY OF AGING

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

(2016) Wenzhong Yang et al.   NEUROBIOLOGY OF AGING

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease

(2015) Wioletta Rozpedek et al.   CURRENT MEDICINAL CHEMISTRY

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions

(2015) Julia Behnke et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage ofBLOC1S1mRNA by IRE1 Is Sequence Specific, Temporally Separate fromXBP1Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

(2015) Michael D. Bright et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of axon regeneration by the RNA repair and splicing pathway

(2015) Yuanquan Song et al.   NATURE NEUROSCIENCE

Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

(2015) Audrey Filézac de L'Etang et al.   NATURE NEUROSCIENCE

Familial Amyotrophic Lateral Sclerosis

(2015) Kevin Boylan   NEUROLOGIC CLINICS

Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein

(2014) W. S. Jackson   Disease Models & Mechanisms

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

(2014) Deanna L. Howarth et al.   PLoS Genetics

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

(2013) Michael Misiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine

(2013) Praveen Paul et al.   NEUROBIOLOGY OF AGING

Differential molecular chaperone response associated with various mouse adapted scrapie strains

(2013) Ayodeji A. Asuni et al.   NEUROSCIENCE LETTERS

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis

(2012) T. Prell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer's disease and frontotemporal lobar degeneration?

(2012) Olof Lindberg et al.   Frontiers in Aging Neuroscience

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells

(2011) Giovanni Nardo et al.   PLoS One

Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells

(2010) Beth A. Dombroski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

(2010) Han-Jou Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

(2008) Georgia Anagnostou et al.   NEUROBIOLOGY OF AGING

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE