De novo design of protein logic gates

Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry

(2020) Zachary L. VanAernum et al.   Nature Protocols

Deconstructing cell-free extract preparation for in vitro activation of transcriptional genetic circuitry

(2019) Adam Silverman et al.   ACS Synthetic Biology

Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer

(2019) Zachary L. VanAernum et al.   ANALYTICAL CHEMISTRY

Guiding Biomolecular Interactions in Cells Using de Novo Protein–Protein Interfaces

(2019) Abigail J. Smith et al.   ACS Synthetic Biology

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Programmable protein circuits in living cells

(2018) Xiaojing J. Gao et al.   SCIENCE

Cellular checkpoint control using programmable sequential logic

(2018) Lauren B. Andrews et al.   SCIENCE

Programmable design of orthogonal protein heterodimers

(2018) Zibo Chen et al.   NATURE

Design of fast proteolysis-based signaling and logic circuits in mammalian cells

(2018) Tina Fink et al.   Nature Chemical Biology

Complex cellular logic computation using ribocomputing devices

(2017) Alexander A. Green et al.   NATURE

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Synthetic recombinase-based state machines in living cells

(2016) N. Roquet et al.   SCIENCE

Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast

(2016) Andrés Aranda-Díaz et al.   ACS Synthetic Biology

Synthetic Biology Platform for Sensing and Integrating Endogenous Transcriptional Inputs in Mammalian Cells

(2016) Bartolomeo Angelici et al.   Cell Reports

Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

(2016) Benjamin Groves et al.   eLife

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery

(2015) Liliana Wroblewska et al.   NATURE BIOTECHNOLOGY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

High-throughput preparation methods of crude extract for robust cell-free protein synthesis

(2015) Yong-Chan Kwon et al.   Scientific Reports

A Highly Characterized Yeast Toolkit for Modular, Multipart Assembly

(2015) Michael E. Lee et al.   ACS Synthetic Biology

Toehold Switches: De-Novo-Designed Regulators of Gene Expression

(2014) Alexander A. Green et al.   CELL

Accurate SAXS Profile Computation and its Assessment by Contrast Variation Experiments

(2013) Dina Schneidman-Duhovny et al.   BIOPHYSICAL JOURNAL

Synthetic circuits integrating logic and memory in living cells

(2013) Piro Siuti et al.   NATURE BIOTECHNOLOGY

Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution

(2013) A. W. Reinke et al.   SCIENCE

Amplifying Genetic Logic Gates

(2013) J. Bonnet et al.   SCIENCE

A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

(2012) Ahmad S. Khalil et al.   CELL

Programmable single-cell mammalian biocomputers

(2012) Simon Ausländer et al.   NATURE

A tunable zinc finger-based framework for Boolean logic computation in mammalian cells

(2012) Jason J. Lohmueller et al.   NUCLEIC ACIDS RESEARCH

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

How do dynamic cellular signals travel long distances?

(2011) Ruth Nussinov   Molecular BioSystems

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

(2011) L. Qian et al.   SCIENCE

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’

(2010) Alvin Tamsir et al.   NATURE

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble

(2009) Jorge Estrada et al.   BMC BIOINFORMATICS

A General and Rapid Cell-Free Approach for the Interrogation of Protein−Protein, Protein−DNA, and Protein−RNA Interactions and their Antagonists Utilizing Split-Protein Reporters

(2008) Jason R. Porter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY