Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 12, Pages 6890-6900
Publisher
Proceedings of the National Academy of Sciences
Online
2020-03-10
DOI
10.1073/pnas.1909943117
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Loss of Hepatic Oscillatory Fed microRNAs Abrogates Refed Transition and Causes Liver Dysfunctions
- (2019) Babukrishna Maniyadath et al. Cell Reports
- Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock
- (2018) Amandine Chaix et al. Cell Metabolism
- Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases
- (2018) Gabriele Sulli et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity
- (2018) Troy C. Krzysiak et al. MOLECULAR CELL
- Functions and mechanisms of non-histone protein acetylation
- (2018) Takeo Narita et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle
- (2018) Kenichiro Kinouchi et al. Cell Reports
- Emerging roles of SIRT1 in fatty liver diseases
- (2017) Ren-Bo Ding et al. International Journal of Biological Sciences
- Regulation of hepatic glucose metabolism in health and disease
- (2017) Max C. Petersen et al. Nature Reviews Endocrinology
- Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation
- (2017) Aneika C. Leney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
- (2017) Cuifang Han et al. Nature Communications
- Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity
- (2017) Shaunak Deota et al. Cell Reports
- SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
- (2016) Danli Kong et al. AGING CELL
- The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
- (2016) M. Madan Babu BIOCHEMICAL SOCIETY TRANSACTIONS
- Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
- (2016) Valter D. Longo et al. Cell Metabolism
- Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice
- (2016) C. E. Geisler et al. Nutrition & Metabolism
- Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism
- (2016) Fabin Dang et al. Scientific Reports
- AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance
- (2016) Laia Vil et al. Molecular Therapy-Methods & Clinical Development
- Ubiquitinated Sirtuin 1 (SIRT1) Function Is Modulated during DNA Damage-induced Cell Death and Survival
- (2015) Lirong Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs
- (2015) Fiorella Ghisays et al. Cell Reports
- Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges
- (2014) Amandine Chaix et al. Cell Metabolism
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- (2014) Basil P. Hubbard et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- O-GlcNAc Cycling: A Link Between Metabolism and Chronic Disease
- (2013) Michelle R. Bond et al. Annual Review of Nutrition
- Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms
- (2013) Shaodong Guo JOURNAL OF ENDOCRINOLOGY
- The ways and means that fine tune Sirt1 activity
- (2013) Javier R. Revollo et al. TRENDS IN BIOCHEMICAL SCIENCES
- SIRT1 and energy metabolism
- (2012) X. Li ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation
- (2012) Maarten R. Soeters et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
- (2012) Megumi Hatori et al. Cell Metabolism
- Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
- (2012) Chao Tong et al. FASEB JOURNAL
- JNK2-dependent regulation of SIRT1 protein stability
- (2011) Jack Ford et al. CELL CYCLE
- Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets
- (2011) Deepti Ramachandran et al. FEBS Journal
- Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis
- (2011) Sarawut Jitrapakdee INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity
- (2011) Min Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
- (2011) Zhanguo Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- (2011) Simon Schenk et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- (2011) Rui-Hong Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
- (2011) Tsuneaki Kawashima et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
- (2011) Judith Y. Altarejos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
- (2011) Dongmei Wu et al. PLoS One
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- (2011) N. R. Sundaresan et al. Science Signaling
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation
- (2010) Fen Xu et al. ENDOCRINOLOGY
- SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
- (2010) Bhaskar Ponugoti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
- (2010) Ji-Hong Lim et al. MOLECULAR CELL
- O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress
- (2009) Chutikarn Butkinaree et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
- (2009) Aparna Purushotham et al. Cell Metabolism
- PPAR control: it's SIRTainly as easy as PGC
- (2009) Mary C Sugden et al. JOURNAL OF ENDOCRINOLOGY
- SIRT1 and insulin resistance
- (2009) Fengxia Liang et al. Nature Reviews Endocrinology
- CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
- (2009) Hyeog Kang et al. PLoS One
- JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
- (2009) Nargis Nasrin et al. PLoS One
- Energetic cell sensors: a key to metabolic homeostasis
- (2009) Mourad Naïmi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- SIRTUIN 1: Regulating the regulator
- (2008) Barbara Zschoernig et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
- (2008) Alexander S. Banks et al. Cell Metabolism
- Regulation of SIRT1 protein levels by nutrient availability
- (2008) Yariv Kanfi et al. FEBS LETTERS
- Regulation of theO-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling
- (2008) Stephen A. Whelan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DBC1 is a negative regulator of SIRT1
- (2008) Ja-Eun Kim et al. NATURE
- Phosphorylation Regulates SIRT1 Function
- (2008) Tsutomu Sasaki et al. PLoS One
- Sirt1 protects against high-fat diet-induced metabolic damage
- (2008) P. T. Pfluger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The ups and downs of SIRT1
- (2008) Hye-Sook Kwon et al. TRENDS IN BIOCHEMICAL SCIENCES
- O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity
- (2008) Tarik Issad et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started