Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

Mitochondrial respiratory chain complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug

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Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

(2019) Reika Shiratori et al.   Scientific Reports

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

(2018) Anup Ramachandran et al.   GENE EXPRESSION

Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis

(2018) Eun-Hee Cho   Frontiers in Endocrinology

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

(2018) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

(2017) Daniel J. Tyrrell et al.   Oxidative Medicine and Cellular Longevity

Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction

(2017) Susan Giorgi-Coll et al.   Scientific Reports

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

(2016) Laszlo Tretter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling

(2016) Łukasz P Zieliński et al.   MITOCHONDRION

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency

(2016) Johannes K. Ehinger et al.   Nature Communications

Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health

(2016) Daniel J. Tyrrell et al.   Redox Biology

Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone

(2015) Sebastian Prill et al.   ARCHIVES OF TOXICOLOGY

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition

(2014) S. Piel et al.   Acta Physiologica

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

(2014) Mitchell R McGill et al.   Expert Opinion on Drug Metabolism & Toxicology

Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury

(2014) Kang Kwang Lee et al.   HEPATOLOGY

Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cells

(2014) FUGEN WANG et al.   Experimental and Therapeutic Medicine

Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets

(2014) Philip A. Kramer et al.   Jove-Journal of Visualized Experiments

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers

(2014) Philip A. Kramer et al.   Redox Biology

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial respiration in human viable platelets—Methodology and influence of gender, age and storage

(2012) Fredrik Sjövall et al.   MITOCHONDRION

Mouse mtDNA mutant model of Leber hereditary optic neuropathy

(2012) C. S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding lactic acidosis in paracetamol (acetaminophen) poisoning

(2010) Anoop D. Shah et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

The role of the GPR91 ligand succinate in hematopoiesis

(2009) Yaron Hakak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Acetylcysteine for Acetaminophen Poisoning

(2008) Kennon J. Heard   NEW ENGLAND JOURNAL OF MEDICINE

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic β-cells through restoration of mitochondrial electron transfer

(2007) S A Hinke et al.   BRITISH JOURNAL OF PHARMACOLOGY