The transition from local to global patterns governs the differentiation of mouse blastocysts

Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins

(2019) Hiroshi Kiyonari et al.   GENESIS

Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells

(2019) Masakazu Hashimoto et al.   DEVELOPMENTAL CELL

What does time mean in development?

(2018) Miki Ebisuya et al.   DEVELOPMENT

GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm

(2018) Yue Meng et al.   DEVELOPMENTAL BIOLOGY

A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice

(2018) Sophie M. Morgani et al.   DEVELOPMENTAL BIOLOGY

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Making lineage decisions with biological noise: Lessons from the early mouse embryo

(2018) Claire S. Simon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Mouse ICM Organoids Reveal Three-Dimensional Cell Fate Clustering

(2018) Biena Mathew et al.   BIOPHYSICAL JOURNAL

In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level

(2018) Katie McDole et al.   CELL

A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse

(2018) Claire S. Simon et al.   Biology Open

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation

(2017) Hisham Mohammed et al.   Cell Reports

Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

(2017) Eszter Posfai et al.   eLife

Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids

(2017) Alexander Schmitz et al.   Scientific Reports

Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway

(2017) M. Wigger et al.   Scientific Reports

β-catenin-mediated adhesion is required for successful preimplantation mouse embryo development

(2016) Daniel Messerschmidt et al.   DEVELOPMENT

Defined three-dimensional microenvironments boost induction of pluripotency

(2016) Massimiliano Caiazzo et al.   NATURE MATERIALS

Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

(2016) Néstor Saiz et al.   Nature Communications

Emerging Role of the Hippo Signaling Pathway in Position Sensing and Lineage Specification in Mammalian Preimplantation Embryos1

(2015) Chanchao Lorthongpanich et al.   BIOLOGY OF REPRODUCTION

A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice

(2015) Laina Freyer et al.   BMC DEVELOPMENTAL BIOLOGY

FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells

(2015) C. Schro ter et al.   DEVELOPMENT

BMP signaling is required for cell cleavage in preimplantation-mouse embryos

(2015) Nabora Soledad Reyes de Mochel et al.   DEVELOPMENTAL BIOLOGY

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

(2015) J.-E. Dietrich et al.   EMBO REPORTS

Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells

(2015) Sissy E. Wamaitha et al.   GENES & DEVELOPMENT

The p38 MAPK signalling pathway is required for glucose metabolism, lineage specification and embryo survival during mouse preimplantation development

(2015) Berna Sozen et al.   MECHANISMS OF DEVELOPMENT

Single cells get together: High-resolution approaches to study the dynamics of early mouse development

(2015) Néstor Saiz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent

(2015) Aleksandar I. Mihajlović et al.   Scientific Reports

Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst

(2015) Panagiotis Xenopoulos et al.   Cell Reports

Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

(2014) G. C. Le Bin et al.   DEVELOPMENT

Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network

(2014) S. Bessonnard et al.   DEVELOPMENT

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

(2014) Teresa Rayon et al.   DEVELOPMENTAL CELL

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

(2014) Thorsten Boroviak et al.   NATURE CELL BIOLOGY

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

(2014) Sung-Hyun Kim et al.   Stem Cell Research

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

(2014) Sarah J. L. Graham et al.   Nature Communications

A Rapid and Efficient 2D/3D Nuclear Segmentation Method for Analysis of Early Mouse Embryo and Stem Cell Image Data

(2014) Xinghua Lou et al.   Stem Cell Reports

Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst

(2013) N. Saiz et al.   DEVELOPMENT

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

(2013) Yusuke Ohnishi et al.   NATURE CELL BIOLOGY

FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse

(2012) M. Kang et al.   DEVELOPMENT

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

(2012) F. Lavial et al.   GENES & DEVELOPMENT

Control of ground-state pluripotency by allelic regulation of Nanog

(2012) Yusuke Miyanari et al.   NATURE

The structure of Wntch signalling and the resolution of transition states in development

(2012) Silvia Muñoz Descalzo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Correlations Between the Levels of Oct4 and Nanog as a Signature for Naïve Pluripotency in Mouse Embryonic Stem Cells

(2012) Silvia Muñoz Descalzo et al.   STEM CELLS

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

(2012) N. Perrimon et al.   Cold Spring Harbor Perspectives in Biology

Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo

(2011) J. B. Grabarek et al.   DEVELOPMENT

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

Cell Surface Heparan Sulfate Chains Regulate Local Reception of FGF Signaling in the Mouse Embryo

(2011) Kayo Shimokawa et al.   DEVELOPMENTAL CELL

Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo

(2011) Pawel Krupinski et al.   PLoS Computational Biology

Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism

(2010) Daniel M. Messerschmidt et al.   DEVELOPMENTAL BIOLOGY

Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

(2010) Guoji Guo et al.   DEVELOPMENTAL CELL

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst

(2009) Sigolène M. Meilhac et al.   DEVELOPMENTAL BIOLOGY

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

(2008) B. Plusa et al.   DEVELOPMENT

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst

(2007) François Gerbe et al.   DEVELOPMENTAL BIOLOGY

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

(2007) Noriyuki Nishioka et al.   MECHANISMS OF DEVELOPMENT