Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Advances in drug discovery for human beta cell regeneration

(2018) Esra Karakose et al.   DIABETOLOGIA

Replication confers β cell immaturity

(2018) Sapna Puri et al.   Nature Communications

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

(2017) Heather L. Hayes et al.   PLoS One

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

(2017) Samuel B. Stephens et al.   Cell Reports

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

(2016) Sangeeta Dhawan et al.   DIABETES

A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation

(2016) Heather L. Hayes et al.   MOLECULAR AND CELLULAR BIOLOGY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

Nkx6.1 regulates islet  -cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

(2014) J. S. Tessem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function

(2012) Samuel B. Stephens et al.   Cell Metabolism

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

cMyc Is a Principal Upstream Driver of β-Cell Proliferation in Rat Insulinoma Cell Lines and Is an Effective Mediator of Human β-Cell Replication

(2011) Esra Karslioglu et al.   MOLECULAR ENDOCRINOLOGY

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Stimulation of Human and Rat Islet  -Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1

(2008) J. C. Schisler et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY