Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes

Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model

(2020) Bo Chen et al.   Frontiers in Pharmacology

Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions

(2020) Xiaojiaoyang Li et al.   Cells

Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells

(2019) Xuehong Wang et al.   Lipids in Health and Disease

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3

(2019) Xi Xu et al.   FASEB JOURNAL

The role of sphingosine kinase 2 in alcoholic liver disease

(2019) Eric K. Kwong et al.   DIGESTIVE AND LIVER DISEASE

Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

(2019) Lingyan Wu et al.   Cell Death & Disease

Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway

(2019) Xiaopeng Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Saturated Fatty Acid Combined with Lipopolysaccharide Stimulates a Strong Inflammatory Response in Hepatocytes in vivo and in vitro

(2018) Yanchun Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

(2017) Yongqing Wang et al.   HEPATOLOGY

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy

(2017) Junli Ma et al.   Nutrients

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

(2016) Xinxia Chang et al.   Journal of Translational Medicine

The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

(2016) Xiaopeng Zhu et al.   MOLECULES

Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells

(2016) J. Haywood et al.   OSTEOARTHRITIS AND CARTILAGE

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress

(2016) Zhiguo Zhang et al.   Scientific Reports

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Role of bioactive fatty acids in nonalcoholic fatty liver disease

(2015) Eva Juárez-Hernández et al.   Nutrition Journal

Obesity and the gastrointestinal microbiota: a review of associations and mechanisms

(2015) C. Graham et al.   NUTRITION REVIEWS

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

(2015) Hong-Mei Yan et al.   PLoS One

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER stress and hepatic lipid metabolism

(2014) Huiping Zhou et al.   Frontiers in Genetics

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

(2013) Junfei Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages

(2013) Weibin Zha et al.   PLoS One

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor-induced hepatic lipotoxicity in mice

(2012) Yun Wang et al.   HEPATOLOGY

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

(2010) Weibin Zha et al.   PLoS One

Cellular responses to endoplasmic reticulum stress and apoptosis

(2009) Vanya I. Rasheva et al.   APOPTOSIS

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

(2009) Li Chen et al.   BIOCHEMICAL PHARMACOLOGY

HIV Protease Inhibitors Induce Endoplasmic Reticulum Stress and Disrupt Barrier Integrity in Intestinal Epithelial Cells

(2009) Xudong Wu et al.   GASTROENTEROLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY