Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload

The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways

(2016) Bong Sook Jhun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

Mitochondrial Ca 2+ and ROS formation in cardiac injury and protection

(2016) Fabio Di Lisa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter

(2016) Cristina Mammucari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics

(2016) Guillermo U. Ruiz-Esparza et al.   EUROPEAN JOURNAL OF HEART FAILURE

From the RNA world to the clinic

(2016) B. A. Sullenger et al.   SCIENCE

From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase

(2015) P. Bernardi et al.   CIRCULATION RESEARCH

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials

(2015) Kangxing Song et al.   Oxidative Medicine and Cellular Longevity

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Delivery systems for siRNA drug development in cancer therapy

(2015) Cong-fei Xu et al.   Asian Journal of Pharmaceutical Sciences

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity

(2014) E Fernández-Sada et al.   BRITISH JOURNAL OF PHARMACOLOGY

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Acetylcholine Mediates AMPK-Dependent Autophagic Cytoprotection in H9c2 Cells During Hypoxia/Reoxygenation Injury

(2013) Mei Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of Altered Ca 2+ Handling in Heart Failure

(2013) Min Luo et al.   CIRCULATION RESEARCH

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Ischemia–reperfusion induces myocardial infarction through mitochondrial Ca2+ overload

(2012) Kaori Shintani-Ishida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An Update on Cardioprotection

(2012) Paul Z. Gerczuk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria:Low and high affinity effects of cyclosporine A

(2011) An-Chi Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

(2011) DJ Hausenloy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

(2010) Shiang Y. Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria and reperfusion injury of the heart—A holey death but not beyond salvation

(2009) Andrew P. Halestrap   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction

(2008) Kívia A. P. Oliveira et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS