Tetraspanin CD82 drives acute myeloid leukemia chemoresistance by modulating protein kinase C alpha and β1 integrin activation

Mechanisms of drug resistance in acute myeloid leukemia

(2019) Jing Zhang et al.   OncoTargets and Therapy

CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/β-catenin signaling pathway

(2019) Hongyan Ji et al.   PEDIATRIC RESEARCH

Hematopoietic stem-cell transplantation in children with refractory acute myeloid leukemia

(2019) Yasuhiro Okamoto et al.   BONE MARROW TRANSPLANTATION

Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia

(2019) Sofiane Berrazouane et al.   Cell Death & Disease

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Mesenchymal stem cells confer chemoresistance in breast cancer via a CD9 dependent mechanism

(2019) Mujib Ullah et al.   Oncotarget

Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells

(2018) Mayu Takami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting FLT3 Mutations in Acute Myeloid Leukemia

(2018) Riad El Fakih et al.   Cells

The Tetraspanin CD82 regulates Bone Marrow Homing and Engraftment of Hematopoietic Stem and Progenitor Cells

(2018) Chelsea A. Saito-Reis et al.   MOLECULAR BIOLOGY OF THE CELL

Functional genomic landscape of acute myeloid leukaemia

(2018) Jeffrey W. Tyner et al.   NATURE

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes

(2017) Candace A. Frerich et al.   Oncotarget

Optimized approach for Ion Proton RNA sequencing reveals details of RNA splicing and editing features of the transcriptome

(2017) Roger B. Brown et al.   PLoS One

Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

(2016) Ja Min Byun et al.   ANNALS OF HEMATOLOGY

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

(2016) L. Bachegowda et al.   CANCER RESEARCH

Constitutive NF-κB activation in AML: Causes and treatment strategies

(2016) Matthieu Cornelis Johannes Bosman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

β3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD

(2016) Madhumathy G. Nair et al.   EXPERIMENTAL CELL RESEARCH

Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma

(2016) Michael Crump et al.   JOURNAL OF CLINICAL ONCOLOGY

Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia

(2016) Thomas Boyer et al.   Oncotarget

Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid Leukemia

(2016) Christina M. Termini et al.   Scientific Reports

SARTools: A DESeq2- and EdgeR-Based R Pipeline for Comprehensive Differential Analysis of RNA-Seq Data

(2016) Hugo Varet et al.   PLoS One

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

(2015) Hyog Young Kwon et al.   Cell Stem Cell

The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells

(2015) C Nishioka et al.   LEUKEMIA

Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin

(2015) K D Marjon et al.   ONCOGENE

Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells

(2015) Chie Nishioka et al.   PLoS One

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma

(2015) K. J. Brayer et al.   Cancer Discovery

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors

(2015) Jalaj Gupta et al.   Oncotarget

Tetraspanins as therapeutic targets in hematological malignancy: a concise review

(2015) Kyle A. Beckwith et al.   Frontiers in Physiology

Sequential Superresolution Imaging of Multiple Targets Using a Single Fluorophore

(2015) Christopher C. Valley et al.   PLoS One

Molecular Target Therapy of AKT and NF-kB Signaling Pathways and Multidrug Resistance by Specific Cell Penetrating Inhibitor Peptides in HL-60 Cells

(2014) Zahra Davoudi et al.   Asian Pacific Journal of Cancer Prevention

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

(2014) A. M. Cook et al.   BLOOD

Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways

(2014) Dalila Naci et al.   CELLULAR SIGNALLING

A Phase I Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes

(2014) G. Garcia-Manero et al.   CLINICAL CANCER RESEARCH

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients

(2013) R. B. Walter et al.   BLOOD

CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells

(2013) Chie Nishioka et al.   INTERNATIONAL JOURNAL OF CANCER

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Nuclear Localization of p38 MAPK in Response to DNA Damage

(2012) C. David Wood et al.   International Journal of Biological Sciences

CD34+/CD38−acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells

(2012) Chie Nishioka et al.   INTERNATIONAL JOURNAL OF CANCER

α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)

(2012) Dalila Naci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers

(2012) Francesco Bonardi et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance

(2011) Hope A. Sansing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissecting the diverse functions of the metastasis suppressor CD82/KAI1

(2011) Yien Che Tsai et al.   FEBS LETTERS

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

(2011) Peter P. Ruvolo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Simultaneous multiple-emitter fitting for single molecule super-resolution imaging

(2011) Fang Huang et al.   Biomedical Optics Express

Cell Surface Tetraspanin CD9 Mediates Chemoresistance in Small Cell Lung Cancer

(2010) S. Kohmo et al.   CANCER RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

(2009) P. Ramirez et al.   BLOOD

Controlling cell surface dynamics and signaling: How CD82/KAI1 suppresses metastasis

(2008) C.K. Miranti   CELLULAR SIGNALLING

Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol

(2008) Moe Wakui et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes

(2008) Melanie J. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

(2008) J A McCubrey et al.   LEUKEMIA