Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

(2014) T. Berg et al.   BLOOD

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF- B mediates chemoresistance

(2014) R. Jacamo et al.   BLOOD

Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

(2014) Koki Ueda et al.   CANCER SCIENCE

Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature

(2014) P. Delgado-Olguin et al.   DEVELOPMENT

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation

(2014) A A Sahasrabuddhe et al.   ONCOGENE

CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells

(2013) Chie Nishioka et al.   INTERNATIONAL JOURNAL OF CANCER

Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies

(2013) S N Khan et al.   LEUKEMIA

EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia

(2013) Xiuli Wang et al.   PLoS One

Fibronectin-α4β1 Interactions in Hepatic Cold Ischemia and Reperfusion Injury: Regulation of MMP-9 and MT1-MMP via the p38 MAPK Pathway

(2012) S. Duarte et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells

(2012) Jing Zou et al.   ANNALS OF HEMATOLOGY

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

(2012) S. Tanaka et al.   BLOOD

STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2

(2012) W. F. Tam et al.   CANCER RESEARCH

Azacytidine inhibits the proliferation of human promyelocytic leukemia cells (HL60) by demethylation ofMGMT,DAPKandp16genes

(2012) Yongchun Su et al.   Hematology

CD34+/CD38−acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells

(2012) Chie Nishioka et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways

(2012) Kentaro Nakayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lower phosphorylation of p38 MAPK blocks the oxidative stress-induced senescence in myeloid leukemic CD34+CD38− cells

(2012) Yin Xiao et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells

(2012) D. Cakouros et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of histone methyltransferase EZH2 in myelodysplastic syndromes

(2012) Feng Xu et al.   Expert Review of Hematology

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

(2011) A. M. Jankowska et al.   BLOOD

Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury

(2011) Yong Wang et al.   RADIATION RESEARCH

Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins

(2011) C Nishioka et al.   Blood Cancer Journal

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Role of the polycomb group proteins in hematopoietic stem cells

(2010) Takaaki Konuma et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+/CD38− cells and sensitizes them to antileukemia agents

(2010) Takayuki Ikezoe et al.   INTERNATIONAL JOURNAL OF CANCER

Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene

(2010) C Nishioka et al.   LEUKEMIA

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

(2010) Shuai Chen et al.   NATURE CELL BIOLOGY

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice

(2009) C. Peng et al.   BLOOD

Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-α via the p38 mitogen-activated protein kinase pathway

(2009) Yanmin Zhang et al.   FASEB JOURNAL

p38α and p38γ Mediate Oncogenicras-induced Senescence through Differential Mechanisms

(2009) Jinny Kwong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK signaling pathways in the regulation of hematopoiesis

(2009) Christian R. Geest et al.   JOURNAL OF LEUKOCYTE BIOLOGY