Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells

(2019) Rafaela Muniz de Queiroz et al.   Frontiers in Oncology

Integrated analysis of gene expression and methylation profiles of novel pancreatic cancer cell lines with highly metastatic activity

(2019) Gang Yang et al.   Science China-Life Sciences

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?

(2019) Wenhao Luo et al.   Cancer Medicine

Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis

(2018) Joana G. Rodrigues et al.   CELLULAR IMMUNOLOGY

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

(2018) Prakash C. Thakur et al.   Journal of Translational Medicine

GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells

(2018) Patricia Dauer et al.   Molecular Oncology

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis

(2018) Francesca Ricciardiello et al.   Cell Death & Disease

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring

(2018) Ferdinando Chiaradonna et al.   Cells

Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer

(2018) Weikun Qian et al.   LIFE SCIENCES

O-GlcNAc: A Sweetheart of the Cell Cycle and DNA Damage Response

(2018) Caifei Liu et al.   Frontiers in Endocrinology

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

(2018) Mengyu Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metabolic Dependencies in Pancreatic Cancer

(2018) Ali Vaziri-Gohar et al.   Frontiers in Oncology

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

Pancreatic Cancer Chemoresistance to Gemcitabine

(2017) Manoj Amrutkar et al.   Cancers

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

(2016) Cecilia Lopez-Sambrooks et al.   Nature Chemical Biology

Gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) Yoav Binenbaum et al.   DRUG RESISTANCE UPDATES

Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling

(2015) Takushi Namba et al.   Marine Drugs

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells

(2013) H. M. Itkonen et al.   CANCER RESEARCH

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of β-catenin and cell proliferation

(2011) Stéphanie Olivier-Van Stichelen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

(2011) N. S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein O-GlcNAcylation: A Critical Regulator of the Cellular Response to Stress

(2010) John Chatham et al.   Current Signal Transduction Therapy

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE