Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

(2019) Hongcheng Wang et al.   Cancer Cell International

Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer

(2019) Carlotta Spano et al.   Scientific Reports

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

(2018) Chunwan Lu et al.   BMC CANCER

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

(2018) Lorraine A. O’Reilly et al.   IMMUNITY

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

(2018) Prakash C. Thakur et al.   Journal of Translational Medicine

GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells

(2018) Patricia Dauer et al.   Molecular Oncology

MELATONIN AND ITS METABOLITE N1-ACETYL-N2-FORMYL-5-METHOXYKYNURAMINE (AFMK) ENHANCE CHEMOSENSITIVITY TO GEMCITABINE IN PANCREATIC CARCINOMA CELLS (PANC-1)

(2018) Anna Leja-Szpak et al.   Pharmacological Reports

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

(2018) Davide Pastorelli et al.   PHARMACOLOGICAL RESEARCH

Combination of PI3K/Akt Pathway Inhibition and Plk1 Depletion Can Enhance Chemosensitivity to Gemcitabine in Pancreatic Carcinoma

(2018) Yonghuan Mao et al.   Translational Oncology

Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway

(2018) Chao Yu et al.   Theranostics

Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10

(2018) Louisa Stern et al.   Journal of Cancer

USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy

(2018) Tao Ma et al.   CANCER LETTERS

Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy

(2018) Rudradip Pattanayak et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

(2018) Jie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk

(2018) D. Moschovis et al.   Cancer Biomarkers

Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch-1 signaling pathway in pancreatic cancer

(2018) Long Cui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b

(2018) Liguo Hao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

(2018) Xiang Ling et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207

(2018) Lei You et al.   Molecular Oncology

Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer

(2018) Shibin Qu et al.   Epigenomics

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

(2018) Ming-Chuan Hsu et al.   Cancers

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)

(2017) Guanggai Xia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer

(2017) Jacob M. Smigiel et al.   MOLECULAR CANCER RESEARCH

Sclareolide enhances gemcitabine-induced cell death through mediating the NICD and Gli1 pathways in gemcitabine-resistant human pancreatic cancer

(2017) Sheng Chen et al.   Molecular Medicine Reports

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance

(2017) Hee Seung Lee et al.   Scientific Reports

Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis

(2016) Chenggang Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer

(2016) Pei Fan et al.   CANCER LETTERS

IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma

(2016) Song Gao et al.   CANCER RESEARCH

New treatment strategy with nuclear factor-κB inhibitor for pancreatic cancer

(2016) Takashi Horiuchi et al.   JOURNAL OF SURGICAL RESEARCH

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells

(2016) Jing-Jing Zhang et al.   Oncotarget

Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential

(2016) Jason J. Kwon et al.   Oncotarget

Leptin-Notch signaling axis is involved in pancreatic cancer progression

(2016) Adriana Harbuzariu et al.   Oncotarget

Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation

(2016) Shiro Kohi et al.   Journal of Oncology

Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress

(2016) Carman K. M. Ip et al.   Scientific Reports

Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

(2015) Huan Meng et al.   ACS Nano

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

(2015) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

(2015) C. Duluc et al.   EMBO Molecular Medicine

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

(2015) Zhihua Li et al.   Journal of Translational Medicine

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

(2015) Ming-Chen Yang et al.   Molecular Cancer

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells

(2015) Shuhei Suzuki et al.   Oncotarget

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer

(2014) B. Alagesan et al.   CLINICAL CANCER RESEARCH

HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters (Review)

(2014) XUAN NI et al.   Oncology Letters

Desmoplasia and Chemoresistance in Pancreatic Cancer

(2014) Marvin Schober et al.   Cancers

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

(2013) Enza Lonardo et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Expression of MicroRNAs in Patients With Pancreatic Cancer and Its Prognostic Significance

(2012) Ioannis G. Papaconstantinou et al.   PANCREAS

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gemcitabine Induces the VMP1 -Mediated Autophagy Pathway to Promote Apoptotic Death in Human Pancreatic Cancer Cells

(2010) Romina Pardo et al.   PANCREATOLOGY

Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer

(2009) Chitta Ranjan Patra et al.   ADVANCED DRUG DELIVERY REVIEWS

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY