Review
Neurosciences
Nasim Bahram Sangani, Ana Rita Gomes, Leopold M. G. Curfs, Chris P. Reutelingsperger
Summary: Extracellular Vesicles (EVs) are membrane particles secreted by cells, carrying various biomolecules to facilitate communication between neural cells. They play a crucial role in CNS development by stimulating neural cell proliferation, differentiation, and mediating interactions between neurons and oligodendrocytes during myelination. Understanding the presence and contribution of EVs in CNS developmental milestones is essential for research in this area.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Biology
Vasiliki Pantazou, Thomas Roux, Vanessa Oliveira Moreira, Catherine Lubetzki, Anne Desmazieres
Summary: Multiple sclerosis is a complex inflammatory disease of the central nervous system characterized by neurodegeneration and demyelination. Understanding the mechanisms of remyelination is crucial for promoting neuroprotection and limiting disease progression. The interaction between neurons and the oligodendroglial lineage plays a significant role in potential therapeutic strategies for supporting remyelination and neuroprotection in MS.
Review
Cell Biology
Su-Ran Li, Qi-Wen Man, Xin Gao, Hao Lin, Jing Wang, Fu-Chuan Su, Han-Qi Wang, Lin-Lin Bu, Bing Liu, Gang Chen
Summary: Extracellular vesicles (EVs) are lipid-bilayer membrane structures secreted by most cell types, acting as messengers through the transfer of lipids, proteins, and nucleic acids to influence cellular processes. Tissue-derived EVs (Ti-EVs) offer advantages such as tissue specificity and accurate reflection of the tissue microenvironment, playing important roles in intercellular communication and disease development insights. Current research on Ti-EVs is limited compared to body fluid or cell culture-derived EVs, highlighting the need for further exploration in basic and clinical applications.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Cell & Tissue Engineering
Riccardo Bazzoni, Ilaria Tanasi, Nice Turazzi, Mauro Krampera
Summary: Extracellular vesicles (EVs) are released by cells and contain various bioactive molecules, playing a crucial role in intercellular communication and biological processes. In hematological malignancies, EVs contribute to tumor development, drug resistance, and bone marrow microenvironment modulation. EVs have potential as diagnostic biomarkers, therapeutic targets, and drug carriers.
Review
Biochemistry & Molecular Biology
Tamara Camino, Nerea Lago-Baameiro, Maria Pardo
Summary: Extracellular vesicles (EVs) are nanosized lipid bilayer spheres that have emerged as new metabolic players in energy homeostasis and intercellular communication. They carry bioactive molecules and serve as a source of biomarkers and drug-delivery vehicles. The research on the role of EVs in metabolism, obesity, and associated pathologies is rapidly increasing. This review focuses on adipose tissue shed EVs, their characterization, size profile, and molecular cargo content, and also discusses the deleterious effects of EVs released by obese adipose tissue at both local and distant levels.
Article
Cell Biology
Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos, Esther S. Oh, Dimitrios Kapogiannis
Summary: The hallmarks of Alzheimer's disease (AD) pathology are senile plaques containing amyloid-beta (A beta) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanisms are involved in AD, especially synaptic degeneration, which necessitate the need for synaptic integrity-related biomarkers alongside A beta- and tau-related biomarkers. Plasma neuron-derived Extracellular Vesicles (NDEVs) provide biomarkers related to A beta and tau and synaptic degeneration. Higher levels of NDEV A beta(42) were consistently associated with better cognitive status, memory, fluency, working memory, and executive function. Higher levels of NDEV synaptic integrity-related biomarkers were associated with better performance on executive function tasks. Our findings support the hypothesis that releasing A beta(42)-laden NDEVs may be an adaptive mechanism in AD.
Review
Neurosciences
Miranda D. Horn, Andrew G. MacLean
Summary: Extracellular vesicles (EVs) are used by cells for intercellular communication, transferring important molecules including viruses. Research shows that EVs can encapsulate viruses, leading to issues like antibody neutralization and neurodegeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Diana M. Morales-Prieto, Jose M. Murrieta-Coxca, Milan Stojiljkovic, Celia Diezel, Priska E. Streicher, Julian A. Henao-Restrepo, Franziska Roestel, Julia Lindner, Otto W. Witte, Sebastian Weis, Christian Schmeer, Manja Marz
Summary: Extracellular vesicles, specifically small EVs, are involved in neuroinflammation and neurodegenerative diseases. Aging brains show increased neuroinflammation and glial activation, which can be influenced by EVs. Our study demonstrates that sEVs from aged mice can cross the blood-brain barrier and induce glial cell activation in young animals.
Review
Oncology
Kenza Dubois, Mariana Tannoury, Brigitte Bauvois, Santos A. Susin, Delphine Garnier
Summary: Chronic lymphocytic leukemia (CLL) is a type of cancer characterized by the accumulation of abnormal B lymphocytes in the immune system. Despite the development of new therapies, drug resistance and disease relapse still occur. The interactions between leukemic B cells and the microenvironment play a crucial role in treatment resistance. Extracellular vesicles released into the microenvironment have emerged as key players in this cross-talk and can potentially be targeted for novel therapeutics.
Review
Biochemistry & Molecular Biology
Zhengke Zhi, Qiaochu Sun, Weibing Tang
Summary: Extracellular vesicles (EV) are vesicular structures with phospholipid bilayer, found in biological fluids and the extracellular microenvironment. They play a crucial role in intercellular communication by delivering lipids, proteins, and RNAs to recipient cells. Tissue derived extracellular vesicles (Ti-EVs), distinct from those derived from biofluids and cell culture, provide us with more accurate and enriched information about the tissue microenvironment, participating directly in the crosstalk between various cell types within the microenvironment. The study of Ti-EVs is increasing as they have the potential to accurately reflect the occurrence and development of human diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Layla Simon, Sofia Sanhueza, Belen Gaete-Ramirez, Manuel Varas-Godoy, Andrew F. G. Quest
Summary: Advances in cancer biology have led to different treatments for improving patients' survival rates. However, relapse and recurrence remain common due to therapy resistance in residual cancer cells, which is influenced by the inflammatory tumor microenvironment (TME) and extracellular vesicles (EVs). Inflammatory conditions alter the release and composition of EVs within the TME, affecting tumor cells' response to cancer therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tahani Bakhsh, Safiah Alhazmi, Najla Ali Alburae, Ali Farsi, Faisal Alzahrani, Hani Choudhry, Ahmed Bahieldin
Summary: Colorectal cancer is a common type of cancer worldwide, and early diagnosis is crucial for effective treatment. Current blood biomarkers for CRC diagnosis are not accurate enough. Studies have found that specific miRNAs in extracellular vesicles can be used as noninvasive biomarkers for the screening and diagnosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Shahzad Ahmad, Rohit K. Srivastava, Pratibha Singh, Ulhas P. Naik, Amit K. Srivastava
Summary: Cross talk between glia and neurons is crucial for various biological functions, and extracellular vesicles (EVs) play a critical role in this communication by transporting substances to alter the structure and function of target cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shizhen Shen, Zhangjin Shen, Conghui Wang, Xiaodong Wu, Lingfang Wang, Lele Ye, Songfa Zhang, Xiaodong Cheng
Summary: In this study, a method for extracting extracellular vesicles (EVs) from epithelial ovarian cancer (EOC) tissues was optimized to investigate the effect of cryopreservation on the phenotypes, contents, and biological functions of the extracted EVs. The results showed that cryopreservation affected the yield and distribution of EVs, but not their morphology or particle mass ratio. The storage of tissues at -80°C increased both small and large EV yields, while the storage of lysates at -80°C decreased large EV yield and increased small EV yield. The cryopreserved EOC tissue retained a high percentage of proteins and miRNAs, and the extracted EVs could promote angiogenesis and invasive migration ability in human endothelial cells. This suggests that cryopreserved EOC tissue has clinical value for studying tissue-derived EVs, especially those related to EV proteins.
Review
Neurosciences
Damaris Nieves Torres, Sang H. Lee
Summary: Conventional inter-neuronal communication is wired and occurs through chemical synapses, but recent studies suggest that neurons can also communicate wirelessly through small extracellular vesicles (EVs). These small EVs, including exosomes, contain various signaling molecules and can be absorbed by recipient cells. Neuronal small EVs have been found to affect multiple neuronal functions. This volume transmission mediated by small EVs is important for activity-dependent changes in neuronal function and the regulation of local circuitry. In this review, recent discoveries and the potential scope of small EV-mediated inter-neuronal signaling are summarized.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Chaitali Mukherjee, Tina Kling, Belisa Russo, Kerstin Miebach, Eva Kess, Martina Schifferer, Liliana D. Pedro, Ulrich Weikert, Maryam K. Fard, Nirmal Kannaiyan, Moritz Rossner, Marie-Louise Aicher, Sandra Goebbels, Klaus-Armin Nave, Eva-Maria Kramer-Albers, Anja Schneider, Mikael Simons
Article
Medicine, General & Internal
Lusine Danielyan, Matthias Schwab, Georg Siegel, Bianca Brawek, Olga Garaschuk, Nithi Asavapanumas, Marine Buadze, Ali Lourhmati, Hans-Peter Wendel, Meltem Avci-Adali, Marcel A. Krueger, Carsten Calaminus, Ulrike Naumann, Stefan Winter, Elke Schaeffeler, Annett Spogis, Sandra Beer-Hammer, Jonas J. Neher, Gabriele Spohn, Anja Kretschmer, Eva-Maria Kramer-Albers, Kerstin Barth, Hong Jun Lee, Seung U. Kim, William H. Frey, Claus D. Claussen, Dirk M. Hermann, Thorsten R. Doeppner, Erhard Seifried, Christoph H. Gleiter, Hinnak Northoff, Richard Schaefer
Article
Medicine, General & Internal
Richard Schaefer, Matthias Schwab, Georg Siegel, Andreas von Ameln-Mayerhofer, Marine Buadze, Ali Lourhmati, Hans-Peter Wendel, Torsten Kluba, Marcel A. Krueger, Carsten Calaminus, Eva Scheer, Massimo Dominici, Giulia Grisendi, Thorsten R. Doeppner, Jana Schlechter, Anne Kathrin Finzel, Dominic Gross, Roland Klaffschenkel, Frank K. Gehring, Gabriele Spohn, Anja Kretschmer, Karen Bieback, Eva-Maria Kraemer-Albers, Kerstin Barth, Anne Eckert, Stefanie Elser, Joerg Schmehl, Claus D. Claussen, Erhard Seifried, Dirk M. Hermann, Hinnak Northoff, Lusine Danielyan
Article
Biochemistry & Molecular Biology
Carsten Fruehbeis, Wen Ping Kuo-Elsner, Christina Mueller, Kerstin Barth, Leticia Peris, Stefan Tenzer, Wiebke Moebius, Hauke B. Werner, Klaus-Armin Nave, Dominik Froehlich, Eva-Maria Kraemer-Albers
Review
Physiology
Alexandra Brahmer, Elmo W. I. Neuberger, Perikles Simon, Eva-Maria Kraemer-Albers
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Genetics & Heredity
Elmo W. Neuberger, Barlo Hillen, Katharina Mayr, Perikles Simon, Eva-Maria Kraemer-Albers, Alexandra Brahmer
Summary: This study investigated the association of cell-free circulating DNA (cfDNA) and cancer-derived extracellular vesicles (EVs) in healthy human plasma. It found that only a small portion of cfDNA is associated with EVs, primarily on the outer surface. Exercise was shown to increase the levels of EVs, cfDNA, and EV-associated DNA, with the majority of DNA being located on the outer surface of circulating EVs rather than in their lumen.
Editorial Material
Neurosciences
Eva-Maria Kraemer-Albers
Summary: Axon integrity relies on support from glial cells for maintenance and energy balance. The transfer of SIRT2 from oligodendrocytes to axons via extracellular vesicles enhances axonal energy production by deacetylating mitochondrial proteins.
Article
Multidisciplinary Sciences
Ann-Kathrin Volz, Alina Frei, Viola Kretschmer, Antonio M. de Jesus Domingues, Rene F. Ketting, Marius Ueffing, Karsten Boldt, Eva-Maria Kramer-Albers, Helen L. May-Simera
Summary: The study reveals the role of ciliary proteins in extracellular vesicle biogenesis, showing that specific ciliary mutations lead to increased secretion and altered cargo composition of small EVs. Additionally, these small EVs are found to modulate the WNT response in recipient cells, providing insights into ciliary signaling mechanisms involved in ciliopathy disease pathogenesis.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Tobias J. Buscham, Maria A. Eichel-Vogel, Anna M. Steyer, Olaf Jahn, Nicola Strenzke, Rakshit Dardawal, Tor R. Memhave, Sophie B. Siems, Christina Muller, Martin Meschkat, Ting Sun, Torben Ruhwedel, Wiebke Mobius, Eva-Maria Kramer-Albers, Susann Boretius, Klaus-Armin Nave, Hauke B. Werner, Kelly Monk
Summary: CMTM5 plays a role in maintaining axonal integrity rather than myelin biogenesis, as its deficiency leads to early-onset progressive axonopathy without affecting the development or ultrastructure of myelin.
Article
Neurosciences
Eva-Maria Kraemer-Albers
Summary: EVs interact with the blood-brain barrier to facilitate communication between the brain and periphery. They can be released, act on, or cross the barrier, exerting wide-ranging effects on brain-periphery communication in both healthy and pathological states.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Eva-Maria Kraemer-Albers, Hauke B. Werner
Summary: Extracellular vesicles (EVs) have been identified as important mediators of cell communication in the nervous system, particularly between oligodendrocytes and neurons. EVs play a crucial role in maintaining the structural integrity of axons by delivering key factors that improve axonal transport, stress resistance, and energy homeostasis. Dysfunction in glial support and the transfer of EVs can lead to loss of axonal integrity observed in myelin-related disorders, neurodegenerative diseases, and ageing. Understanding the mechanisms of EV-mediated interactions is essential for therapeutic applications.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Cell Biology
Alexandra Brahmer, Carsten Geiss, Andriani Lygeraki, Elmo Neuberger, Theophilos Tzaridis, Tinh Thi Nguyen, Felix Luessi, Anne Regnier-Vigouroux, Gunther Hartmann, Perikles Simon, Kristina Endres, Stefan Bittner, Katrin S. Reiners, Eva-Maria Kraemer-Albers
Summary: Extracellular vesicles (EVs) released by cells carry specific biomolecules that can be used as liquid-biopsy markers for diagnosing brain diseases. This study evaluated a flow cytometry platform called EV Neuro assay for identifying and characterizing CNS-derived EVs and disease-specific markers in complex samples. The study compared different sample materials and EV isolation methods and found distinct EV profiles in glioblastoma cell lines and human astrocytes. The intensity of EV markers increased with higher EV input. Analysis of blood samples from patients with brain diseases and healthy controls showed varying EV marker intensities between individuals. Data normalization improved the identification of disease-specific markers. The EV Neuro assay proved useful for profiling EVs in complex samples. However, larger sample cohorts and higher effect sizes are needed for more reliable results in biomarker studies. Nonetheless, this study confirmed the potential of the EV Neuro assay for discovering disease-associated EV markers and monitoring circulating EV profiles in CNS diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Laura Dietz, Jennifer Oberlaender, Ana Mateos-Maroto, Jenny Schunke, Michael Fichter, Eva-Maria Kraemer-Albers, Katharina Landfester, Volker Mailaender
Summary: This study analyzed the protein composition of extracellular vesicles (EVs) and the protein corona around EVs in human blood plasma using a proteomic approach. The influence of the protein corona on the uptake of EVs by human monocytes was then compared with the uptake of engineered liposomes. The results showed that the presence of a protein corona increased the uptake of EVs in human monocytes, indicating a clear difference between EVs and liposomes as nanocarriers.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Biochemistry & Molecular Biology
Andrea Schnatz, Christina Mueller, Alexandra Brahmer, Eva-Maria Kraemer-Albers
Summary: Extracellular vesicles (EVs) play a crucial role in CNS homeostasis by serving as versatile messengers in intercellular communication. They are involved in various physiological processes such as clearance of cellular components, mediation of trophic support, promotion of axonal maintenance, and modulation of neuroinflammation. Novel transgenic models and imaging technologies provide deeper insights into the functions and mechanisms of EVs in the nervous system.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
