Update on the Role and Utility of Extracellular Vesicles in Hematological Malignancies

Human myeloma cell‐ and plasma‐derived extracellular vesicles contribute to functional regulation of stromal cells

(2021) Antonia Reale et al.   PROTEOMICS

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells

(2021) Weijiang Liu et al.   Stem Cell Research & Therapy

Extracellular vesicles shed by follicular lymphoma B cells promote the polarization of bone marrow stromal cell niche

(2021) Erwan Dumontet et al.   BLOOD

Extracellular vesicles from dHL-60 cells as delivery vehicles for diverse therapeutics

(2021) Jun-Kyu Kim et al.   Scientific Reports

Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4

(2021) Tianxin Lyu et al.   Experimental Hematology & Oncology

Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARα transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients

(2021) Mohieddin Barzegar et al.   ANNALS OF HEMATOLOGY

Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment

(2021) Xiangyu Tian et al.   LEUKEMIA RESEARCH

Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP

(2021) Ling Zhang et al.   OncoTargets and Therapy

Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression

(2021) Shabirul Haque et al.   Cancer Genetics

Inhibition of Exosome Release Sensitizes U937 Cells to PEGylated Liposomal Doxorubicin

(2021) Shirin Hekmatirad et al.   Frontiers in Immunology

Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway

(2021) Hui Cheng et al.   MOLECULAR MEDICINE

Bone marrow‐mesenchymal stem cell‐derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro

(2021) Jitrada Phetfong et al.   FEBS Open Bio

Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia

(2021) Meixi Peng et al.   Journal of Extracellular Vesicles

Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics

(2020) Evangelia Kontopoulou et al.   ANNALS OF HEMATOLOGY

Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia

(2020) Tobias Herold et al.   LEUKEMIA

Effect of the extracellular component of bone marrow mesenchymal stromal cells from healthy donors on hematologic neoplasms and their angiogenesis

(2020) Nina Gladkova et al.   Human Cell

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

(2020) Austin Gowen et al.   Frontiers in Cell and Developmental Biology

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

(2020) Wei Hu et al.   Molecular Cancer

Technologies and Standardization in Research on Extracellular Vesicles

(2020) Srujan Gandham et al.   TRENDS IN BIOTECHNOLOGY

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

(2020) Lavinia Raimondi et al.   Cancers

Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

(2020) Stefania Trino et al.   LEUKEMIA

MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression

(2020) Danqing Xin et al.   PHARMACOLOGICAL RESEARCH

Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

(2020) Xiaoyan Zhang et al.   Stem Cells International

Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related peripheral neuropathy

(2020) Yanyu Zhang et al.   CELLULAR SIGNALLING

Detection of AML-specific mutations in pediatric patient plasma using extracellular vesicle–derived RNA

(2019) Fabienne Kunz et al.   ANNALS OF HEMATOLOGY

Diffuse Large B cell Lymphoma: 2019 update on diagnosis, risk-stratification and treatment

(2019) Yang Liu et al.   AMERICAN JOURNAL OF HEMATOLOGY

Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

(2019) Eva Rohde et al.   CYTOTHERAPY

Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling

(2019) Matthew Ho et al.   LEUKEMIA

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

(2019) Nathalie Javidi-Sharifi et al.   eLife

Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends

(2019) Gargiulo et al.   Cells

Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells

(2019) Eleonora Stronati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation

(2019) Sang-Soo Lee et al.   Cell Communication and Signaling

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

(2019) Thierry Burnouf et al.   International Journal of Nanomedicine

Multiple myeloma-derived exosomes inhibit osteoblastic differentiation and improve IL-6 secretion of BMSCs from multiple myeloma

(2019) Zhaoyun Liu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Cancer-Derived Extracellular Vesicle-Associated MicroRNAs in Intercellular Communication: One Cell’s Trash Is Another Cell’s Treasure

(2019) Joseph Mills et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway

(2018) Ying Liu et al.   CYTOTHERAPY

Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

(2018) Bin Zhang et al.   CYTOTHERAPY

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

(2018) Valentina Giudice et al.   HAEMATOLOGICA

miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding

(2018) Danyue Peng et al.   LEUKEMIA

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models

(2018) Folashade Otegbeye et al.   PLoS One

Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model

(2018) Hyewon Park et al.   YONSEI MEDICAL JOURNAL

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

(2018) Valentina Giudice et al.   HAEMATOLOGICA

Exosome-derived miRNAs as predictive biomarkers for diffuse large B-cell lymphoma chemotherapy resistance

(2018) Yuhua Feng et al.   Epigenomics

Understanding extracellular vesicle diversity – current status

(2018) David W. Greening et al.   Expert Review of Proteomics

A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD

(2018) Peilong Lai et al.   Journal of Hematology & Oncology

Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes

(2018) Maria Antonia Frassanito et al.   JOURNAL OF PATHOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Prognostic factors for multiple myeloma in the era of novel therapies

(2018) Dimitrios C. Ziogas et al.   Expert Review of Hematology

Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts

(2018) Sylvia Faict et al.   Blood Cancer Journal

To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles

(2018) Gina D. Kusuma et al.   Frontiers in Pharmacology

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications

(2017) Emerence Crompot et al.   HAEMATOLOGICA

DCOne as an Allogeneic Cell-based Vaccine for Multiple Myeloma

(2017) Rebecca Karp Leaf et al.   JOURNAL OF IMMUNOTHERAPY

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo

(2017) Céline Bouvy et al.   LEUKEMIA RESEARCH

Exosomes: New players in cancer

(2017) Wei Guo et al.   ONCOLOGY REPORTS

Micro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis

(2017) Juliana Barrera-Ramirez et al.   Stem Cell Reviews and Reports

Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

(2017) Sumie Fujii et al.   STEM CELLS

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications

(2017) Emerence Crompot et al.   HAEMATOLOGICA

Micro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis

(2017) Juliana Barrera-Ramirez et al.   Stem Cell Reviews and Reports

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

(2016) Taral R. Lunavat et al.   BIOMATERIALS

Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells

(2016) D. T. Smallwood et al.   BLOOD

TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

(2016) L. Rivoltini et al.   CLINICAL CANCER RESEARCH

MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1

(2016) Yajie Zhang et al.   International Journal of Biological Sciences

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression

(2016) J Boysen et al.   LEUKEMIA

CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D

(2016) H Bruns et al.   LEUKEMIA

Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

(2016) Luciana De Luca et al.   LEUKEMIA & LYMPHOMA

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Extracellular Vesicles Released from Human Umbilical Cord-Derived Mesenchymal Stromal Cells Prevent Life-Threatening Acute Graft-Versus-Host Disease in a Mouse Model of Allogeneic Hematopoietic Stem Cell Transplantation

(2016) Li Wang et al.   STEM CELLS AND DEVELOPMENT

MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

(2016) Antonella Caivano et al.   CELLULAR ONCOLOGY

Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma

(2016) Jinheng Wang et al.   Oncotarget

Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

(2016) Li Zhang et al.   Oncotarget

Isolation of Human CD138+ Microparticles from the Plasma of Patients with Multiple Myeloma

(2016) Sabna Rajeev Krishnan et al.   NEOPLASIA

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients

(2016) Sandra Muntión et al.   PLoS One

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

(2016) Mariano Di Trapani et al.   Scientific Reports

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

(2015) J. Paggetti et al.   BLOOD

Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling

(2015) Y.-Y. Yeh et al.   BLOOD

Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance

(2015) Shelton Viola et al.   BRITISH JOURNAL OF HAEMATOLOGY

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(2015) Basile Stamatopoulos et al.   MOLECULAR MEDICINE

CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p

(2015) Mosavar Farahani et al.   PLoS One

High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

(2015) Antonella Caivano et al.   TUMOR BIOLOGY

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

(2015) Lavinia Raimondi et al.   Oncotarget

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

Plasma Exosomes as Markers of Therapeutic Response in Patients with Acute Myeloid Leukemia

(2014) Chang-Sook Hong et al.   Frontiers in Immunology

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity

(2013) K. S. Reiners et al.   BLOOD

miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor

(2013) Keiichiro Iida et al.   Cancer Cell International

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Role of microRNAs in Cytogenetically Normal Acute Myeloid Leukemia:miR-155Upregulation Independently Identifies High-Risk Patients

(2013) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

(2013) Suyan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

(2012) Daniela Zech et al.   Cell Communication and Signaling

Intercellular communication: diverse structures for exchange of genetic information

(2012) Maria Mittelbrunn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Mesenchymal stromal cell ‘licensing’: a multistep process

(2011) M Krampera   LEUKEMIA

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY