NLRP3 inflammasome and endoplasmic reticulum stress in the epileptogenic zone in temporal lobe epilepsy: molecular insights into their interdependence

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders

(2019) Ting Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Neurodegenerative disease treatments by direct TNF reduction, SB623 cells, maraviroc and irisin and MCC950, from an inflammatory perspective – a Commentary

(2019) I A Clark et al.   Expert Review of Neurotherapeutics

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome

(2019) Eloise Lemarchand et al.   STROKE

Inhibition of TRIB3 Protects Against Neurotoxic Injury Induced by Kainic Acid in Rats

(2019) Jing Zhang et al.   Frontiers in Pharmacology

Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

(2019) Sun-Ji Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review

(2019) Danbin Wu et al.   INFLAMMATION

The role of inflammation in the development of epilepsy

(2018) Amna Rana et al.   Journal of Neuroinflammation

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

(2018) Daniela M. Magalhães et al.   Journal of Neuroinflammation

ROS signaling and ER stress in cardiovascular disease

(2018) Cristhiaan D. Ochoa et al.   MOLECULAR ASPECTS OF MEDICINE

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

(2018) E. A. van Vliet et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

NLRP3 Inflammasome Activation Leads to Epileptic Neurona l Apoptosis

(2018) Kai Shen et al.   CURRENT NEUROVASCULAR RESEARCH

Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system

(2018) Neil T. Sprenkle et al.   JOURNAL OF NEUROCHEMISTRY

Increased expression of (immuno)proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of rapamycin pathway

(2017) Diede W. M. Broekaart et al.   EPILEPSIA

Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures

(2017) Rebecca Brulet et al.   EXPERIMENTAL NEUROLOGY

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress

(2017) Xinjian Zhu et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage

(2017) Xinjian Zhu et al.   Frontiers in Cellular Neuroscience

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

(2016) Je-Wook Yu et al.   ARCHIVES OF PHARMACAL RESEARCH

The metabolomic signature of Leber’s hereditary optic neuropathy reveals endoplasmic reticulum stress

(2016) Juan Manuel Chao de la Barca et al.   BRAIN

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model

(2016) Jiong Yue et al.   EXPERIMENTAL NEUROLOGY

Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

(2016) Fei-Ji Sun et al.   Journal of Neuroinflammation

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Brain Endoplasmic Reticulum Stress Mechanistically Distinguishes the Saline-Intake and Hypertensive Response to Deoxycorticosterone Acetate–SaltNovelty and Significance

(2015) Fusakazu Jo et al.   HYPERTENSION

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

(2014) Yong-Jie Zhang et al.   ACTA NEUROPATHOLOGICA

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

Role of Inflammatory Mediators in the Pathogenesis of Epilepsy

(2014) Tadayuki Shimada et al.   MEDIATORS OF INFLAMMATION

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

(2014) Rafal M. Kaminski et al.   Neurotherapeutics

Stressed to death – mechanisms of ER stress-induced cell death

(2013) Natalia Sovolyova et al.   BIOLOGICAL CHEMISTRY

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

Love and death: microglia, NLRP3 and the Alzheimer's brain

(2013) Tobias Goldmann et al.   CELL RESEARCH

K+ Drops Tilt the NLRP3 Inflammasome

(2013) Thirumala-Devi Kanneganti et al.   IMMUNITY

Kir6.2 knockout aggravates lipopolysaccharide-induced mouse liver injury via enhancing NLRP3 inflammasome activation

(2013) Ren-Hong Du et al.   JOURNAL OF GASTROENTEROLOGY

ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension

(2012) Colin N. Young et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

(2012) Casey M. O'Dell et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS