Article
Food Science & Technology
Ningyang Li, Chaofan Wang, Milen I. Georgiev, Vivek K. Bajpai, Rosa Tundis, Jesus Simal-Gandara, Xiaoming Lu, Jianbo Xiao, Xiaozhen Tang, Xuguang Qiao
Summary: Polysaccharides as anticancer agents have great potential for application, but their complex structure and unclear mechanism of action have hindered their research and clinical application.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Hezhen Wang, Zhiyuan Wang, Chunyong Wei, Jing Wang, Yingshu Xu, Guohui Bai, Qizheng Yao, Lei Zhang, Yongzheng Chen
Summary: Indirubin is a crucial ingredient in Chinese traditional medicine for treating leukemia. Despite its attractive anticancer profile, limitations like low water solubility and poor pharmacokinetic properties have hindered its clinical application. Researchers are exploring novel derivatives of indirubin with improved pharmacological profiles for cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Chinweike Cosmas Eze, Amarachukwu Mercy Ezeokonkwo, Izuchukwu David Ugwu, Uchenna Florence Eze, Ebuka Leonard Onyeyilim, Izuchi Solomon Attah, Ifeoma Vivian Okonkwo
Summary: This review provides an overview of the molecular structures, structure-activity relationship, and molecular docking studies of pyrimidine-fused azole compounds with significant anticancer activity. It serves as an important reference for the design of new and potent anticancer drugs.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Andrei V. Bogdanov, Margarita Neganova, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Igor A. Litvinov, Olga Tsivileva, Nurgali Akylbekov, Rakhmetulla Zhapparbergenov, Zulfiia Valiullina, Alexandr V. Samorodov, Igor Alabugin
Summary: A series of new fluorinated isatins were synthesized via a simple one-pot procedure. These new isatins exhibit antitumor activity, anti-aggregation activity, and antagonistic effect against plant pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
A. Ahmadi, E. Mohammadnejadi, P. Karami, N. Razzaghi-Asl
Summary: Fungal infections have been a major cause of infectious-related deaths, especially with the rise of immune-compromising conditions like HIV. Fungal pathogens, being eukaryotes, are more difficult to eliminate compared to bacterial infections. Research on the structure-activity relationships and chemical diversity of antifungal azoles is important for combating drug-resistant fungal species.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Teodora Constantinescu, Claudiu N. Lungu
Summary: Cancer is a disease caused by various mechanisms, and targeted therapy is the most effective approach. Flavonoids, particularly chalcones, show promising anticancer activity due to their ability to act on multiple targets. Modifying chalcone structures can lead to compounds with superior cytotoxic properties, with derivatives containing different heterocycles like azoles showing potential as new anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Lian-Shun Feng, Wen-Qi Su, Jin-Bo Cheng, Tao Xiao, Hong-Ze Li, De-An Chen, Zhi-Liu Zhang
Summary: Benzimidazole derivatives have diverse anticancer properties, including interference with cell division, induction of apoptosis, and blockage of glucose transport. Benzimidazole hybrids can exhibit dual or multiple antiproliferative activities and have the potential to overcome drug resistance. This article provides a comprehensive landscape of benzimidazole hybrids as potential anticancer agents, discussing the structure-activity relationship and mechanisms of action.
ARCHIV DER PHARMAZIE
(2022)
Review
Chemistry, Medicinal
Shu Zhang, Yun Ye, Qiang Zhang, Yang Luo, Zi-Chen Wang, Yi-Zhe Wu, Xiang-Pu Zhang, Chuan Yi
Summary: This article highlights the recent advances in pyrazole-azole hybrids with anticancer potential, discussing the structure-activity relationships to facilitate the rational design of more effective anticancer candidates.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Wan-Li Tan, Chun Zhang, Yang Li, Kai Guo, Xiao-Wei Gao, Jun Wei, Dong Yi, Lin Pu, Qin Wang
Summary: In this study, 40 optically active falcarindiol analogues were synthesized and their anticancer activities on various cell lines were evaluated. The results indicated that the falcarindiol analogue (3R,8S)-2 i with a terminal double bond exhibited the most potent anti-proliferation effect on Hccc-9810 cells, inducing apoptosis through increased LDH release and MDA content, and decreased SOD activity, leading to oxidative stress accumulation.
Review
Chemistry, Medicinal
Gaoli Dong, Yingchun Jiang, Feng Zhang, Fengyun Zhu, Junna Liu, Zhi Xu
Summary: Cancer is a leading cause of death worldwide and chemotherapeutics play a critical role in cancer therapy. Triazine derivatives have shown potential as anticancer agents due to their excellent pharmacological profiles and ability to overcome drug resistance and reduce side effects. This review focuses on the anticancer activity, structure-activity relationships, and mechanisms of action of 1,2,3-, 1,2,4-, and 1,3,5-triazine hybrids developed from 2017 to the present.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Medicinal
Ruo Wang, Qianru Zhang, Min Chen
Summary: In this study, eleven artemisinin-isatin hybrids tethered via ethylene linker were synthesized and evaluated for their antiproliferative activity against lung cancer cell lines and cytotoxicity towards normal lung epithelial cells. The results showed that these hybrids exhibited potential activity against the cancer cell lines while being non-toxic to normal cells. Moreover, one representative hybrid showed even better potency than traditional chemotherapy drugs and demonstrated excellent safety and selectivity.
ARCHIV DER PHARMAZIE
(2023)
Review
Chemistry, Medicinal
Zhen Wang, Yongxia Xiong, Ying Peng, Xi Zhang, Shuang Li, Yan Peng, Xue Peng, Linsheng Zhuo, Weifan Jiang
Summary: Natural product evodiamine (Evo) is a potential drug lead with multifunctional pharmacological properties, however, its suboptimal biological activity and poor pharmacokinetics hinder its clinical application. Medicinal chemists have successfully produced synthetic analogs to overcome these deficiencies and enhance its anticancer activities. This review focuses on the structural basis, anti-cancer activities, and mechanisms of Evo and its derivatives, providing insights into optimizing strategies for the development of novel anticancer drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Min Dong, Guili Zheng, Feng Gao, Min Li, Chen Zhong
Summary: A series of dihydroartemisinin-isatin hybrids were designed and synthesized, and their antiproliferative activity against lung cancer cell lines was evaluated. The hybrids showed significant activity, surpassing the activity of dihydroartemisinin and artemisinin. In particular, hybrid 6a demonstrated comparable activity to common chemotherapeutic drugs and showed higher potency against multidrug-resistant lung cancer cell lines. Furthermore, hybrid 6a exhibited good selectivity and stability, making it a promising candidate for further development as an anti-lung cancer chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Lian-Shun Feng, Chuan Gao, Fa-Wu Liu, Xiao-Ping Wang, Zhi-Liu Zhang
Summary: Cancer is a major cause of death, and chemotherapy is an effective treatment. However, issues such as multidrug resistance, lack of efficacy, and toxic side effects limit its effectiveness. Quinoxaline hybrids, as important templates, have shown anticancer activity and significant in vitro and in vivo efficacy against various cancers, making them valuable for the development of more effective anticancer drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhe Zhang, Dong Zhang, Yanhui Zhou, Feifei Wang, An Xin, Feng Gao, Peng Wang, Peng Zhang
Summary: A series of propylene tethered compounds were designed and synthesized, and their antiproliferative activity against lung cancer cell lines was evaluated. Among them, hybrid 6f showed promising activity against drug-resistant lung cancer cells and low cytotoxicity towards normal lung cells. It also exhibited acceptable stability in vitro and in vivo.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
