Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly

Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases

(2020) Guendalina Rossi et al.   JOURNAL OF CELL BIOLOGY

HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE

(2020) Hongki Song et al.   eLife

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and aSNAP

(2019) Eric A Prinslow et al.   eLife

Tethering guides fusion-competenttrans-SNARE assembly

(2019) Hongki Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab5 GTPases are required for optimal TORC2 function

(2018) Melissa N. Locke et al.   JOURNAL OF CELL BIOLOGY

A short region upstream of the yeast vacuolar Qa-SNARE heptad-repeats promotes membrane fusion through enhanced SNARE complex assembly

(2017) Hongki Song et al.   MOLECULAR BIOLOGY OF THE CELL

HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex

(2017) Amy Orr et al.   MOLECULAR BIOLOGY OF THE CELL

Multivalent Rab interactions determine tether-mediated membrane fusion

(2017) Anna Lürick et al.   MOLECULAR BIOLOGY OF THE CELL

Improved reconstitution of yeast vacuole fusion with physiological SNARE concentrations reveals an asymmetric Rab(GTP) requirement

(2016) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Multiple conformations of a single SNAREpin between two nanodisc membranes reveal diverse pre-fusion states

(2014) Jaeil Shin et al.   BIOCHEMICAL JOURNAL

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

(2014) Michael Zick et al.   eLife

A distinct tethering step is vital for vacuole membrane fusion

(2014) Michael Zick et al.   eLife

Real-Time Observation of Multiple-Protein Complex Formation with Single-Molecule FRET

(2013) Woori Bae et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes

(2013) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Contributions of Vacuolar Qabc- and R-SNARE Proteins to Membrane Fusion Specificity

(2011) Ryota Izawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1

(2011) Francesca Morgera et al.   MOLECULAR BIOLOGY OF THE CELL

HOPS Initiates Vacuole Docking by Tethering Membranes before trans-SNARE Complex Assembly

(2010) Christopher M. Hickey et al.   MOLECULAR BIOLOGY OF THE CELL

Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

(2010) Clemens W. Ostrowicz et al.   TRAFFIC

The Major Role of the Rab Ypt7p in Vacuole Fusion Is Supporting HOPS Membrane Association

(2009) Christopher M. Hickey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capture and release of partially zipped trans-SNARE complexes on intact organelles

(2009) Matthew L. Schwartz et al.   JOURNAL OF CELL BIOLOGY

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones

(2008) Joji Mima et al.   EMBO JOURNAL