Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases

Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine

(2019) Paolo Monciardini et al.   JOURNAL OF NATURAL PRODUCTS

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

(2019) Tadeja Lukežič et al.   ACS Chemical Biology

Cloning and identification of the Frigocyclinone biosynthetic gene cluster from Streptomyces griseus strain NTK 97

(2019) Jian Mo et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

How structural subtleties lead to molecular diversity for the type III polyketide synthases

(2019) Hiroyuki Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis

(2019) Zhiwei Qin et al.   Nature Communications

Probing the Flexibility of an Iterative Modular Polyketide Synthase with Non-Native Substrates in Vitro

(2018) Samuel C. Curran et al.   ACS Chemical Biology

Polyketide synthases as a platform for chemical product design

(2018) Amin Zargar et al.   AICHE JOURNAL

Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation

(2018) Danyao Du et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

(2018) Xun Guo et al.   BIOCHEMISTRY

Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056

(2018) Chun Gui et al.   Marine Drugs

Engineering strategies for rational polyketide synthase design

(2018) Maja Klaus et al.   NATURAL PRODUCT REPORTS

A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii

(2018) Natalie Heimerl et al.   PLANT JOURNAL

Enhanced doxorubicin production by Streptomyces peucetius using a combination of classical strain mutation and medium optimization

(2018) Xiaoru Wang et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

(2018) Lin Jiang et al.   Frontiers in Chemistry

The architectures of iterative type I PKS and FAS

(2018) Dominik A. Herbst et al.   NATURAL PRODUCT REPORTS

Expanding the Chemical Palette of Industrial Microbes: Metabolic Engineering for Type III PKS-Derived Polyketides

(2018) Claire M. Palmer et al.   Biotechnology Journal

Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases

(2017) Alexandre Faille et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibacterial Paramagnetic Quinones from Actinoallomurus

(2017) Marianna Iorio et al.   JOURNAL OF NATURAL PRODUCTS

ClusterCAD: a computational platform for type I modular polyketide synthase design

(2017) Clara H Eng et al.   NUCLEIC ACIDS RESEARCH

Evolution inspired engineering of antibiotic biosynthesis enzymes

(2017) M. Metsä-Ketelä   ORGANIC & BIOMOLECULAR CHEMISTRY

Characterization of Three Tailoring Enzymes in Dutomycin Biosynthesis and Generation of a Potent Antibacterial Analogue

(2016) Lei Sun et al.   ACS Chemical Biology

Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process

(2016) Shouliang Yin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Type III Polyketide Synthases: Functional Classification and Phylogenomics

(2016) Yugo Shimizu et al.   CHEMBIOCHEM

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor

(2016) Christy L. Osgood et al.   CLINICAL CANCER RESEARCH

On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems

(2016) Srividhya Sundaram et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure and mechanism of assembly line polyketide synthases

(2016) Thomas Robbins et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Synthetic analog of anticancer drug daunorubicin from daunorubicinone using one-pot enzymatic UDP-recycling glycosylation

(2016) Luan Luong Chu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Overexpression of a pathway specific negative regulator enhances production of daunorubicin in bldA deficient Streptomyces peucetius ATCC 27952

(2016) Anaya Raj Pokhrel et al.   MICROBIOLOGICAL RESEARCH

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

Structural basis for DNA cleavage by the potent antiproliferative agent (–)-lomaiviticin A

(2016) Christina M. Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering

(2015) Urška Lešnik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205

(2015) Dong-Bo Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans

(2015) Ekaterina Shelest et al.   BMC GENOMICS

Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

(2015) Bin Wang et al.   CHEMICAL COMMUNICATIONS

Saccharothrixones A–D, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10

(2015) Maoluo Gan et al.   JOURNAL OF NATURAL PRODUCTS

Uncovering the structures of modular polyketide synthases

(2015) Kira J. Weissman   NATURAL PRODUCT REPORTS

Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters

(2015) Maureen E. Hillenmeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase

(2015) Mei Zhang et al.   Chemical Science

Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation

(2014) Abraham J. Waldman et al.   ORGANIC LETTERS

Analysis and Refactoring of the A-74528 Biosynthetic Pathway

(2013) Jay T. Fitzgerald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Type III polyketide synthases in natural product biosynthesis

(2012) Dayu Yu et al.   IUBMB LIFE

A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis

(2012) Luz E. Núñez et al.   JOURNAL OF MEDICINAL CHEMISTRY

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

The diazofluorene antitumor antibiotics: Structural elucidation, biosynthetic, synthetic, and chemical biological studies

(2011) Seth B. Herzon et al.   NATURAL PRODUCT REPORTS

A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

(2011) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxytetracycline Biosynthesis

(2010) Lauren B. Pickens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning, Sequencing, Heterologous Expression, and Mechanistic Analysis of A-74528 Biosynthesis

(2010) Kathia Zaleta-Rivera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin

(2009) Martina Daum  et al.   CHEMBIOCHEM

Biosynthesis of Actinorhodin and Related Antibiotics: Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster

(2009) Susumu Okamoto et al.   CHEMISTRY & BIOLOGY

Identifying the Minimal Enzymes Required for Anhydrotetracycline Biosynthesis

(2008) Wenjun Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

(2008) Y. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA