The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice

By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion

(2018) Yongqiu Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

(2018) Francesca Romana Rizzo et al.   NEURAL PLASTICITY

Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity

(2018) Xin-wei Liu et al.   ACTA PHARMACOLOGICA SINICA

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

(2018) Ryan J. Bevan et al.   ANNALS OF NEUROLOGY

Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination

(2018) Ruo-Xuan Sui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

T cells take aim at a ubiquitous autoantigen in multiple sclerosis

(2018) Joseph J. Sabatino et al.   Science Translational Medicine

Effects of bilobalide, ginkgolide B and picrotoxinin on GABA A receptor modulation by structurally diverse positive modulators

(2017) Chiu Chin Ng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair

(2017) Yuan Zhang et al.   MOLECULAR THERAPY

The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord

(2017) Arathi Jayaraman et al.   NEUROBIOLOGY OF DISEASE

Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways

(2016) Jian-Ming Zhou et al.   CELL STRESS & CHAPERONES

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

(2016) Roland Martin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The effect of B-cell depletion in the Theiler's model of multiple sclerosis

(2015) Francesca Gilli et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The re-emergence of antigen-specific tolerance as a potential therapy for MS

(2015) Lawrence Steinman   Multiple Sclerosis Journal

The re-emergence of antigen-specific tolerance as a potential therapy for MS

(2015) Lawrence Steinman   Multiple Sclerosis Journal

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

(2014) M Bonora et al.   CELL DEATH AND DIFFERENTIATION

Fasudil mediates cell therapy of EAE by immunomodulating encephalomyelitic T cells and macrophages

(2014) Chun-Yun Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

(2014) Zhilong Jiang et al.   IMMUNOLOGY LETTERS

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

(2014) Navneet Singh et al.   Journal of Neuroinflammation

Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies

(2014) Dean M. Wingerchuk et al.   MAYO CLINIC PROCEEDINGS

Pharmacogenomics of interferon beta and glatiramer acetate response: A review of the literature

(2013) Sunil Mahurkar et al.   AUTOIMMUNITY REVIEWS

Antigen-specific tolerization approaches in multiple sclerosis

(2013) Andreas Lutterotti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia

(2013) WEI-ZU LI et al.   Molecular Medicine Reports

Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats

(2013) Yanyan Yin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

(2013) Conor Mc Guire et al.   TRENDS IN MOLECULAR MEDICINE

Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves

(2012) Li Li et al.   CURRENT DRUG METABOLISM

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors

(2010) SunJa Kim et al.   JOURNAL OF NEUROCHEMISTRY

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex

(2009) Rossana Rossi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis

(2007) Bao-Guo Xiao et al.   MOLECULAR IMMUNOLOGY