Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways

Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats

(2016) Yang Xu et al.   BRAIN RESEARCH BULLETIN

Heptaphylline Induces Apoptosis in Human Colon Adenocarcinoma Cells through Bid and Akt/NF-κB (p65) Pathways

(2015) Chantana Boonyarat et al.   Asian Pacific Journal of Cancer Prevention

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

(2015) Bo Yin et al.   BRAIN RESEARCH

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Neurodegeneration after transient brain ischemia in aged mice: Beneficial effects of bilobalide

(2013) Tina M. Schwarzkopf et al.   BRAIN RESEARCH

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

(2013) Justyna Sosna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

(2013) Haiyun Luan et al.   Journal of Neuroinflammation

TLR4 signaling is involved in the protective effect of propofol in BV2 microglia against OGD/reoxygenation

(2013) Xia Qin et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Expression analysis of genes involved in TLR2-related signaling pathway: Inflammation and apoptosis after ischemic brain injury

(2013) L. Winters et al.   NEUROSCIENCE

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury

(2012) Jin-Hua Gu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Baicalin attenuates proinflammatory cytokine production in oxygen–glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway

(2012) Jincai Hou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide Reduces Inflammatory Responses of Oxygen-Glucose Deprived Rat Microglial Cells via Inhibition of the TLR4 Signaling Pathway

(2012) Jun Wang et al.   NEUROCHEMICAL RESEARCH

Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation

(2012) Xia Qin et al.   NEUROLOGICAL RESEARCH

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

(2011) M Neubert et al.   CELL DEATH AND DIFFERENTIATION

study on the protective effect of the Mixture of Shengmai Powder and Danshen Decoction (生脉散丹参饮合剂) on the myocardium of diabetic cardiomyopathy in the rat model

(2011) Qing Ni et al.   Chinese Journal of Integrative Medicine

Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling

(2011) Hee Jae Yun et al.   EMBO JOURNAL

Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia

(2011) Peng Lv et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells

(2011) Winfried Neuhaus et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca2+ influx

(2011) Shuwei Ma et al.   NEUROTOXICOLOGY

Effect of NF-κB Signaling on Apoptosis in Chronic Inflammation-Associated Carcinogenesis

(2010) H. Wang et al.   CURRENT CANCER DRUG TARGETS

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

(2010) M. Lv et al.   NEUROSCIENCE

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

(2009) Ee Tsin Wong et al.   CLINICAL SCIENCE

Cell cycle inhibition attenuates microglial proliferation and production of IL-1β, MIP-1α, and NO after focal cerebral ischemia in the rat

(2009) Qiang Zhang et al.   GLIA

Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs

(2009) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning

(2009) Jesús M. Pradillo et al.   JOURNAL OF NEUROCHEMISTRY

Panax notoginseng Attenuates the Infarct Volume in Rat Ischemic Brain and the Inflammatory Response of Microglia

(2009) Hye Young Son et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil

(2009) Joong Bum MOON et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Toll-like receptor-4 and cytokine cascade in stroke after exercise

(2009) Nathan Zwagerman et al.   NEUROLOGICAL RESEARCH

Pathogen recognition by innate immunity and its signaling

(2009) Shizuo AKIRA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IκB/NF-κB signaling pathway in a rat model of permanent focal cerebral ischemia

(2008) Xuan Wang et al.   BRAIN RESEARCH

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data

(2008) Sandrine Andrieu et al.   Current Alzheimer Research

Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis

(2008) Xiaomei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

NF-κB signaling in cerebral ischemia

(2008) D.A. Ridder et al.   NEUROSCIENCE