Antigen-specific tolerization approaches in multiple sclerosis

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment

(2013) Agata Walczak et al.   JAMA Neurology

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

(2012) Dàlia Raϊch-Regué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evolution of MS lesions to black holes under DNA vaccine treatment

(2012) Athina Papadopoulou et al.   JOURNAL OF NEUROLOGY

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

(2012) Rajneesh Srivastava et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cell Vaccination Benefits Relapsing Progressive Multiple Sclerosis Patients: A Randomized, Double-Blind Clinical Trial

(2012) Dimitrios Karussis et al.   PLoS One

Immune tolerance in multiple sclerosis

(2011) Joan M. Goverman   IMMUNOLOGICAL REVIEWS

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Antigen-Fixed Leukocytes Tolerize Th2 Responses in Mouse Models of Allergy

(2011) Charles B. Smarr et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

A randomized clinical trial of autologous T-cell therapy in multiple sclerosis: subset analysis and implications for trial design

(2011) Edward Fox et al.   Multiple Sclerosis Journal

A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS

(2011) M. S. Freedman et al.   NEUROLOGY

Immune regulation of multiple sclerosis by transdermally applied myelin peptides

(2010) Maciej Juryńczyk et al.   ANNALS OF NEUROLOGY

Inverse vaccination, the opposite of Jenner’s concept, for therapy of autoimmunity

(2010) L. Steinman   JOURNAL OF INTERNAL MEDICINE

The inverse of immunity

(2010) Elie Dolgin   NATURE MEDICINE

Autologous attenuated T-cell vaccine (Tovaxin®) dose escalation in multiple sclerosis relapsing–remitting and secondary progressive patients nonresponsive to approved immunomodulatory therapies

(2009) B. Loftus et al.   CLINICAL IMMUNOLOGY

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Checkpoints in lymphocyte development and autoimmune disease

(2009) Harald von Boehmer et al.   NATURE IMMUNOLOGY

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

Antigen-specific therapies in MS — Current concepts and novel approaches

(2008) Andreas Lutterotti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis

(2007) Arthur A. Vandenbark et al.   IMMUNOLOGY