Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

(2020) Yingchun Wang et al.   HAEMATOLOGICA

β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

(2020) Silvia Giannini et al.   Nature Communications

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue

(2019) Silvita Fitri Riswari et al.   PLoS Pathogens

Fatal acute hemolytic transfusion reaction due to anti-B from a platelet apheresis unit stored in platelet additive solution

(2019) Raisa Balbuena-Merle et al.   TRANSFUSION

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

(2019) Sean R. Stowell et al.   VOX SANGUINIS

Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets

(2019) Wenchun Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Hyaluronidase-2 regulates the early stages of inflammatory disease in colitis

(2019) Aaron C. Petrey et al.   BLOOD

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

(2019) Thomas G. Scorer et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

(2019) Shahan Syed et al.   Frontiers in Cellular and Infection Microbiology

Glycosaminoglycan Neutralization in Coagulation ControlHighlights

(2018) Amélie I.S. Sobczak et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mutation inGNEis associated with a severe form of congenital thrombocytopenia

(2018) Jane Futterer et al.   BLOOD

Mechanisms of platelet clearance and translation to improve platelet storage

(2018) M. Edward Quach et al.   BLOOD

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

(2018) Irina Pleines et al.   BLOOD

Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease

(2018) Satheesh Chonat et al.   HAEMATOLOGICA

Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease

(2018) Satheesh Chonat et al.   HAEMATOLOGICA

GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting

(2018) Shoshana Revel-Vilk et al.   BLOOD

Towards increasing shelf life and haemostatic potency of stored platelet concentrates

(2018) Shailaja Hegde et al.   CURRENT OPINION IN HEMATOLOGY

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

(2018) Alexandre Kauskot et al.   HAEMATOLOGICA

Inherited thrombocytopenia associated with mutation of UDP-Galactose-4-Epimerase (GALE)

(2018) Aaron Seo et al.   HUMAN MOLECULAR GENETICS

Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity

(2018) Vesla Kullaya et al.   INFECTION AND IMMUNITY

Comparison of the effects of peramivir and oseltamivir on the rise in platelet count in patients with or without proven influenza

(2018) Young-gon Kim et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content

(2018) Nuria Revilla et al.   PLATELETS

Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells

(2017) Yun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent infection progressively disables host protection against intestinal inflammation

(2017) Won Ho Yang et al.   SCIENCE

Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke

(2017) Stephen R. Williams et al.   STROKE

Toward functional assays for assessing the significance of anti-ABO(H) alloantibodies

(2017) Sean R. Stowell   TRANSFUSION

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

(2017) Zongkui Wang et al.   PeerJ

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis

(2017) Thomas R. L. Klei et al.   Frontiers in Immunology

Paroxysmal nocturnal haemoglobinuria

(2017) Anita Hill et al.   Nature Reviews Disease Primers

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged StorageHighlights

(2016) Wenchun Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ABO Blood Group and Risk of Thromboembolic and Arterial DiseaseCLINICAL PERSPECTIVE

(2016) Senthil K. Vasan et al.   CIRCULATION

Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection

(2016) Pierre Bigot et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects

(2016) B. Johnson et al.   HAEMATOLOGICA

Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis

(2016) David A. Hinds et al.   HUMAN MOLECULAR GENETICS

Low-frequency and common genetic variation in ischemic stroke

(2016) Rainer Malik et al.   NEUROLOGY

Discriminating the hemolytic risk of blood type A plasmas using the complement hemolysis using human erythrocytes (CHUHE) assay

(2016) Kenji M. Cunnion et al.   TRANSFUSION

Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population

(2016) Wenjing Zhang et al.   Experimental and Therapeutic Medicine

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects

(2016) B. Johnson et al.   HAEMATOLOGICA

Sialidase inhibition to increase platelet counts: A new treatment option for thrombocytopenia

(2015) Arend Jan Gerard Jansen et al.   AMERICAN JOURNAL OF HEMATOLOGY

Regulating billions of blood platelets: glycans and beyond

(2015) R. Grozovsky et al.   BLOOD

Paroxysmal Cold Hemoglobinuria

(2015) Satish Shanbhag et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

(2015) June Li et al.   Nature Communications

Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects

(2015) Jaewoo Song et al.   PLoS One

Relation of ABO blood groups to the severity of coronary atherosclerosis: An Gensini score assessment

(2014) Ping Gong et al.   ATHEROSCLEROSIS

Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage

(2014) J. Li et al.   HAEMATOLOGICA

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

(2014) Renata Grozovsky et al.   NATURE MEDICINE

GNE myopathy associated with congenital thrombocytopenia: A report of two siblings

(2014) Rumiko Izumi et al.   NEUROMUSCULAR DISORDERS

C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes

(2013) T. Kudo et al.   BLOOD

Thrombosis in paroxysmal nocturnal hemoglobinuria

(2013) A. Hill et al.   BLOOD

The O-linked glycans of human von Willebrand factor modulate its interaction with ADAMTS-13

(2013) A. A. Nowak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

(2013) P. K. Grewal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease

(2013) Martin Dichgans et al.   STROKE

Risks of hemolysis due to anti-A and anti-B caused by the transfusion of blood or blood components containing ABO-incompatible plasma

(2013) Olle Berséus et al.   TRANSFUSION

ABO Blood Group and Risk of Coronary Heart Disease in Two Prospective Cohort Studies

(2012) Meian He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions

(2012) A. A. Nowak et al.   BLOOD

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

(2012) Sean R. Stowell et al.   Clinical & Developmental Immunology

Mammalian sialidases: Physiological and pathological roles in cellular functions

(2012) T. Miyagi et al.   GLYCOBIOLOGY

A Variant In the Abo Gene Explains the Variation in Soluble E-Selectin Levels—Results from Dense Genotyping in Two Independent Populations

(2012) Mahir Karakas et al.   PLoS One

Platelet biogenesis and functions require correct protein O-glycosylation

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-O Blood Type Is the Commonest Genetic Risk Factor for VTE: Results from a Meta-Analysis of the Literature

(2012) Francesco Dentali et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions

(2012) Matthew S. Karafin et al.   TRANSFUSION

Desialylation accelerates platelet clearance after refrigeration and initiates GPIb  metalloproteinase-mediated cleavage in mice

(2011) A. J. G. Jansen et al.   BLOOD

Association of Variation at the ABO Locus With Circulating Levels of Soluble Intercellular Adhesion Molecule-1, Soluble P-selectin, and Soluble E-selectin

(2011) Stefan Kiechl et al.   Circulation-Cardiovascular Genetics

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Human red blood cell aging: correlative changes in surface charge and cell properties

(2011) Yao-Xiong Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

(2011) Muredach P Reilly et al.   LANCET

Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis

(2010) N. L. Smith et al.   BLOOD

Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor

(2010) Nicholas L. Smith et al.   CIRCULATION

Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes

(2010) Lu Qi et al.   HUMAN MOLECULAR GENETICS

Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels

(2010) M. Barbalic et al.   HUMAN MOLECULAR GENETICS

Cosmc is an essential chaperone for correct protein O-glycosylation

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABO-mismatched platelet transfusions: Strategies to mitigate patient exposure to naturally occurring hemolytic antibodies

(2010) Cassandra D. Josephson et al.   TRANSFUSION AND APHERESIS SCIENCE

Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin

(2009) Andrew D. Paterson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual roles for hepatic lectin receptors in the clearance of chilled platelets

(2009) Viktoria Rumjantseva et al.   NATURE MEDICINE

Identification and Characterization of Major Proteins Carrying ABO Blood Group Antigens in the Human Kidney

(2009) Masayuki Tasaki et al.   TRANSPLANTATION

The Asialoglycoprotein Receptor Regulates Levels of Plasma Glycoproteins Terminating with Sialic Acid α2,6-Galactose

(2008) Lindsay M. Steirer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc

(2008) Tongzhong Ju et al.   JOURNAL OF CELL BIOLOGY

The Ashwell receptor mitigates the lethal coagulopathy of sepsis

(2008) Prabhjit K Grewal et al.   NATURE MEDICINE

Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

(2008) Guillaume Paré et al.   PLoS Genetics

Cold antibody autoimmune hemolytic anemias

(2007) Lawrence D. Petz   BLOOD REVIEWS