MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells

The MALT1 locus and peanut avoidance in the risk for peanut allergy

(2019) Alexandra Winters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata

(2018) Benjamin Causton et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Treatment of DSS-induced colitis with mucosal-associated lymphoid tissue lymphoma translocation 1 inhibitor MI-2 is associated with restoration of gut immune function and the microbiota.

(2018) Kyung Won Lee et al.   INFECTION AND IMMUNITY

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth

(2018) Lorena Fontán et al.   JOURNAL OF CLINICAL INVESTIGATION

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

(2017) Maureen Bardet et al.   IMMUNOLOGY AND CELL BIOLOGY

Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis

(2017) Chang Hoon Lee et al.   Scientific Reports

The Paracaspase MALT1

(2016) Janna Hachmann et al.   BIOCHIMIE

The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes

(2016) Inna S Afonina et al.   EMBO REPORTS

MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation

(2016) Anja Schmitt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

(2016) Linda R. Klei et al.   Cell Reports

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MALT1 - a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

(2015) Inna S. Afonina et al.   FEBS Journal

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation

(2015) Benjamin Causton et al.   JOURNAL OF IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma

(2015) Sang Min Lim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction

(2015) Shaquria P. Adderley et al.   MICROCIRCULATION

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

(2015) Constantinos M. Mikelis et al.   Nature Communications

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

(2015) Jong W. Yu et al.   PLoS One

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

Mast Cell Function

(2014) Elaine Zayas Marcelino da Silva et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements

(2014) Judith A. Stolwijk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

(2014) Klaus Heger et al.   PLOS BIOLOGY

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

(2013) Florian Schlauderer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An in vivo Assay to Test Blood Vessel Permeability

(2013) Maria Radu et al.   Jove-Journal of Visualized Experiments

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

From MALT lymphoma to the CBM signalosome

(2011) Shaun Rosebeck et al.   CELL CYCLE

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Pathophysiology of asthma: What has our current understanding taught us about new therapeutic approaches?

(2011) Stephen T. Holgate   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma

(2011) R. A. Ramadas et al.   JOURNAL OF IMMUNOLOGY

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of mast cells in allergic inflammation

(2011) Kawa Amin   RESPIRATORY MEDICINE

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis

(2010) Linda M. McAllister-Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome

(2010) Phillip C. Delekta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCL12/SDF‐1α Activates NF‐κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex

(2010) Aasia O Rehman et al.   International Journal of Oral Science

CARMA3 Mediates Lysophosphatidic Acid–Stimulated Cytokine Secretion by Bronchial Epithelial Cells

(2008) Benjamin D. Medoff et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex

(2008) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY