Article
Multidisciplinary Sciences
Bo Pan, Jing Sun, Ziyu Liu, Lingxiao Wang, Huixia Huo, Yunfang Zhao, Pengfei Tu, Wei Xiao, Jiao Zheng, Jun Li
Summary: In this study, LTC was found to protect against ischemia/reperfusion injury by inhibiting ER stress and MAPK-mediated mechanisms in PC12 cells and animal models. The anti-apoptotic effect of LTC was demonstrated by suppressing the cleavage of PARP, caspase-3, and caspase-9, as well as inhibiting the activation of PERK/eIF2α and IRE1/TRAF2 pathways.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Endocrinology & Metabolism
Min-min Guo, Sheng-biao Qu, Hui-ling Lu, Wen-bo Wang, Mu-Liang He, Jian-Lin Su, Jian Chen, Yong Wang
Summary: Our study demonstrates that biochanin A can alleviate cerebral I/R-induced damage by suppressing apoptosis, ER stress, and p38 MAPK signaling.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Jiang-Wen Yin, Jia Li, Yi-Min Ren, Yan Li, Rui-Xue Wang, Sheng Wang, Yun-Xia Zuo
Summary: The study evaluated the effect of combination therapy with dexmedetomidine and Netrin-1 against ischemic brain injury, finding that the combination therapy can reduce infarct volume and neural damage, decrease apoptosis, and improve OPS recovery rate. The combination therapy also lowers the expression of GRP78 and CHOP, increases MEF2A expression, and promotes ERK5 phosphorylation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Wenhui Tao, Lingui Li, Junkai Hu, Shangxian Xu, Biying Wang, Jun Ding, Mian Zhang, Xiaowen Meng, Xiang Wei, Xisheng Shan, Ke Peng, Huayue Liu, Fuhai Ji
Summary: The interaction between COX-2 and ER stress regulates apoptosis and contributes to myocardial injury induced by ischemia/reperfusion.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Shoaib Manzoor, Daniyah A. Almarghalani, Antonisamy William James, Md Kausar Raza, Tasneem Kausar, Shahid M. Nayeem, Nasimul Hoda, Zahoor A. Shah
Summary: This study found that triazole-pyrimidine hybrid compounds exhibit neuroprotective and anti-inflammatory properties. Several compounds showed significant anti-neuroinflammatory activity by inhibiting the production of nitric oxide and tumor necrosis factor-alpha in human microglia cells. Additionally, several compounds demonstrated promising neuroprotective activity in human neuronal cells by reducing the expression of endoplasmic reticulum chaperone BIP and apoptosis marker cleaved caspase-3.
PHARMACEUTICAL RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Wen Jiang, Wei Zhang, Yuxiang Zhang, Hao Yang, Xiaomei Pan, Qiang Chen, Junhui Chen
Summary: The study investigated the effects of tilianin extracted from Xiangqinglan on the apoptosis of H9c2 cells after oxygen glucose deprivation/reoxygenation (OGD/R), and found that it could inhibit OGD/R-induced cell apoptosis through the mitochondrial pathway and endoplasmic reticulum stress.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jinghuan Wang, Jie Xu, Yejun Dong, Zhenghua Su, Haibi Su, Qianwen Cheng, Xinhua Liu
Summary: Ischemic stroke leads to protein misfolding, calcium imbalance, impaired ER function, and activation of the UPR. This study demonstrates that PARP16 plays a crucial role in the post-ischemic UPR and knocking down PARP16 alleviates brain injury after ischemic stroke. PARP16 functions as an ADP-ribosyltransferase to modulate the UPR through PERK and IRE1α, and its overexpression promotes ER stress-mediated cell damage.
Article
Environmental Sciences
Lihong Zhang, Di Li, Lin Yin, Ce Zhang, Hong Qu, Jianping Xu
Summary: This study investigated the protective role of neuroglobin (Ngb) in rat models of cerebral ischemia/reperfusion (I/R) injury. Ngb overexpression alleviated brain injury by repressing mitochondrial dysfunction and endoplasmic reticulum stress-mediated neuronal apoptosis. Ngb was found to bind to Syt1, and the alleviation of Ngb on I/R-induced injury was partially counteracted by Syt1 knockdown.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M. Haroon A. Choudry, Yong J. Lee
Summary: The combination treatment of glucose deprivation and TRAIL can induce apoptosis in tumor cells through the activation of various caspases, involving the ER stress response pathway and the mitochondria-dependent pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Song Li, Lihua Luo, Yan He, Ruohan Li, Yangfan Xiang, Zhenjie Xing, Yejian Li, Abdullkhaleg Ali Albashari, Xiangyan Liao, Keke Zhang, Liang Gao, Qingsong Ye
Summary: This study aimed to investigate the protective effects of dental pulp stem cell-derived exosomes (DPSC-Exos) against cerebral ischaemia-reperfusion (I/R) injury and explore the underlying mechanism. DPSC-Exos were found to alleviate brain oedema, cerebral infarction, and neurological impairment in I/R mice, potentially through the inhibition of the HMGB1/TLR4/MyD88/NF-κB pathway. Additionally, DPSC-Exos also showed anti-inflammatory effects by reducing the expression of IL-6, IL-1 beta, and TNF-alpha both in vitro and in vivo.
CELL PROLIFERATION
(2021)
Article
Ophthalmology
Xiaorui Wang, Xinxing Zhu, Guangqian Huang, Lili Wu, Zhiyong Meng, Yuyu Wu
Summary: This study investigated the relationship between endoplasmic reticulum stress and Muller glial cells during retinal ischemia and hypoxia. The downregulation of PERK expression had an anti-apoptotic effect on OGD-conditioned rMC-1 cells, suggesting a possible mechanism of MG cell apoptosis during retinal ischemic injury.
Article
Gastroenterology & Hepatology
Yi Yang, Peng Wang, Chaoyi Zhang, Fan Huang, Gaozong Pang, Chuansheng Wei, Changming Lv, Goma Chhetri, Tongcui Jiang, Jun Liu, Yujun Shen, Yuxian Shen
Summary: The study revealed that MANF expression and secretion are significantly upregulated during hepatic I/R. Hepatocyte-specific MANF knockout exacerbates I/R injury by over-activating ER stress. Administration of recombinant human MANF has the potential to alleviate I/R-induced UPR and liver injury.
LIVER INTERNATIONAL
(2021)
Article
Plant Sciences
Yeqing Wang, Shanshan Zhang, Hailai Ni, Yanjie Zhang, Xiaodong Yan, Yue Gao, Beixuan He, Wenzheng Wang, Chong Liu, Meili Guo
Summary: Nicotiflorin, a flavonoid glycoside from traditional Chinese medicine, has shown promise in treating ischemic stroke. This study found that nicotiflorin can alleviate brain damage, improve neurological deficits, and promote autophagy, which plays a significant role in the protective effect of nicotiflorin against ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Ruili Wang, Lei Li, Baogong Wang
Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)