Dexmedetomidine and Netrin-1 Combination Therapy Inhibits Endoplasmic Reticulum Stress by Regulating the ERK5/MEF2A Pathway to Attenuate Cerebral Ischemia Injury

Advances and challenges in stroke rehabilitation

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Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial

(2020) Alparslan Turan et al.   LANCET

BDNF and Netrin-1 repression by C/EBPβ in the gut triggers Parkinson’s disease pathologies, associated with constipation and motor dysfunctions

(2020) Eun Hee Ahn et al.   PROGRESS IN NEUROBIOLOGY

AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice

(2020) Zheng-Da Pang et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2

(2020) Aslihan Terzi et al.   Developmental Neurobiology

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

(2020) Fatemeh Poustchi et al.   Advanced Healthcare Materials

Current endovascular strategies for posterior circulation large vessel occlusion stroke: report of the Society of NeuroInterventional Surgery Standards and Guidelines Committee

(2019) Yasha Kayan et al.   Journal of NeuroInterventional Surgery

Isoflurane Post-conditioning Ameliorates Cerebral Ischemia/Reperfusion Injury by Enhancing Angiogenesis Through Activating the Shh/Gli Signaling Pathway in Rats

(2019) Li Peng et al.   Frontiers in Neuroscience

Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats

(2019) Yulin Zhu et al.   INFLAMMATION

Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury

(2019) Meili Zhai et al.   Aging-US

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling

(2018) Zhihua Yu et al.   Journal of Neuroinflammation

Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway

(2018) Guixing Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuregulin1β Effects on Brain Tissue via ERK5-Dependent MAPK Pathway in a Rat Model of Cerebral Ischemia–Reperfusion Injury

(2017) Ning Gu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway

(2017) Jian Yu et al.   Frontiers in Neuroscience

Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke

(2017) Jian Qiu et al.   Frontiers in Neurology

Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning

(2016) Qin Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

(2016) Xian Su et al.   LANCET

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson’s Disease

(2016) Qimei Wu et al.   MOLECULAR NEUROBIOLOGY

Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery

(2013) Fuhai Ji et al.   CIRCULATION

MEK5/ERK5/mef2: A novel signaling pathway affected by hepatitis C virus non-enveloped capsid-like particles

(2011) Konstantina Katsarou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HB-EGF induces cardiomyocyte hypertrophy via an ERK5-MEF2A-COX2 signaling pathway

(2011) Kuy-Sook Lee et al.   CELLULAR SIGNALLING

miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo

(2011) Yi-Bing Ouyang et al.   NEUROBIOLOGY OF DISEASE

Duplicate preconditioning with sevoflurane in vitro improves neuroprotection in rat brain via activating the extracellular signal-regulated protein kinase

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Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Netrin-1 attenuates ischemic stroke-induced apoptosis

(2008) T.-W. Wu et al.   NEUROSCIENCE