Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome

Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women

(2016) Arnstein Mykletun et al.   BMC GASTROENTEROLOGY

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

(2013) Gerwyn Morris et al.   BMC Medicine

In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation

(2013) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

The nocebo effect: A clinicians guide

(2012) João Data-Franco et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

(2012) Hung Hsuchou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

THE RDOC PROJECT: A NEW PARADIGM FOR INVESTIGATING THE PATHOPHYSIOLOGY OF ANXIETY

(2012) Helen Blair Simpson   DEPRESSION AND ANXIETY

Nutrient intakes and the common mental disorders in women

(2012) Felice N. Jacka et al.   JOURNAL OF AFFECTIVE DISORDERS

The sick role, illness cognitions and outcomes in bipolar disorder

(2012) Michael Berk et al.   JOURNAL OF AFFECTIVE DISORDERS

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

(2012) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats

(2012) Lisa C. Loram et al.   JOURNAL OF PAIN

Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

(2012) Michael Maes et al.   PSYCHIATRY RESEARCH

Inflammatory and Cell-Mediated Immune Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Depression: Inflammatory Markers Are Higher in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome than in Depression

(2012) Michael Maes et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

(2011) Ekua W Brenu et al.   Journal of Translational Medicine

Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices

(2011) T. Hochstrasser et al.   NEUROSCIENCE

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression

(2011) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Psychobiological aspects of somatization syndromes: Contributions of inflammatory cytokines and neopterin

(2011) Frank Euteneuer et al.   PSYCHIATRY RESEARCH

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways

(2010) Michael Maes et al.   BMC Medicine

Role of brain macrophages on IL-1β and fatigue following eccentric exercise-induced muscle damage

(2010) Martin D. Carmichael et al.   BRAIN BEHAVIOR AND IMMUNITY

A formal analysis of cytokine networks in Chronic Fatigue Syndrome

(2010) Gordon Broderick et al.   BRAIN BEHAVIOR AND IMMUNITY

Association of high-sensitivity C-reactive protein with de novo major depression

(2010) Julie A. Pasco et al.   BRITISH JOURNAL OF PSYCHIATRY

Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

(2010) T. Nakamura et al.   Clinical and Vaccine Immunology

Psychometric properties of a scale to measure investment in the sick role: the Illness Cognitions Scale

(2010) Michael Berk et al.   JOURNAL OF EVALUATION IN CLINICAL PRACTICE

Neuronal–immune interactions in mediating stress effects in the etiology and course of schizophrenia: Role of the amygdala in developmental co-ordination

(2010) George Anderson   MEDICAL HYPOTHESES

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

(2010) Cristina Cosi et al.   NEUROPHARMACOLOGY

Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?

(2010) Regina P. Markus et al.   PHARMACOLOGY & THERAPEUTICS

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus

(2010) Koji Ohira et al.   Molecular Brain

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Plasma cytokines in women with chronic fatigue syndrome

(2009) Mary Fletcher et al.   Journal of Translational Medicine

Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain

(2009) Long-Jun Wu et al.   Neurotherapeutics

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

β-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling

(2009) Elzbieta Luchowska et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Tryptophan depletion affects the autonomic stress response in generalized social anxiety disorder

(2009) J. Frederieke van Veen et al.   PSYCHONEUROENDOCRINOLOGY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Immunological aspects of chronic fatigue syndrome

(2008) Lorenzo Lorusso et al.   AUTOIMMUNITY REVIEWS

Depression, anxiety and somatization in primary care: syndrome overlap and functional impairment

(2008) Bernd Löwe et al.   GENERAL HOSPITAL PSYCHIATRY

Reduced serotonergic functioning changes heart rate in ADHD

(2008) Florian Daniel Zepf et al.   JOURNAL OF NEURAL TRANSMISSION

Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases

(2008) Y. Jiang et al.   NEUROBIOLOGY OF DISEASE

Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

(2008) Juan P. Cata et al.   NEUROSCIENCE LETTERS

IFN-gamma mediated pathways in patients with fatigue and chronic active Epstein Barr virus-infection

(2007) Rosa Bellmann-Weiler et al.   JOURNAL OF AFFECTIVE DISORDERS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE