Article
Urology & Nephrology
Yoshiyuki Akiyama, Jimpei Miyakawa, Michael A. O'Donnell, Karl J. Kreder, Yi Luo, Daichi Maeda, Tetsuo Ushiku, Haruki Kume, Yukio Homma
Summary: The study found significant overexpression of HIF1 alpha and up-regulation of its related biological pathways in Hunner lesions, indicating that ischemia and inflammation play a pathophysiological role in this subtype of interstitial cystitis/bladder pain syndrome.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yu-Khun Lee, Hann-Chorng Kuo
Summary: Low-energy shock wave (LESW) therapy, especially when combined with intravesical therapeutic agents, has shown promising results in treating chronic prostatitis and bladder disorders. This novel treatment model has the potential to significantly reduce pain and inflammation, improve symptoms, and enhance the quality of life for patients with IC/BPS.
Article
Urology & Nephrology
J. Curtis Nickel, Garth D. Ehrlich, Jaroslaw E. Krol, Azad Ahmed, Bhaswati Sen, Archana Bhat, Joshua C. Mell, R. Christopher Doiron, Kerri-Lynn Kelly, Joshua P. Earl
Summary: The study examined the urinary microbiota associated with Hunner lesion (HL) interstitial cystitis/bladder pain syndrome (IC/BPS) using molecular diagnostic techniques, finding no significant differences between the bacterial communities of HL and non-HL IC/BPS patients overall. However, male HL patients showed significant differences in specific bacterial species. This suggests that bacteria may not play a significant role in HL IC/BPS patients as a whole.
Article
Medicine, General & Internal
Yoshiyuki Akiyama
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) presents with a wide variety of clinical phenotypes, with Hunner lesion and non-Hunner lesion subtypes having distinct potential pathophysiology. The former is characterized by immunological inflammatory processes and epithelial denudation, while the latter may involve neural system abnormalities and urothelial malfunction. Targeted approaches are essential for identifying reliable disease-specific biomarkers for both subtypes.
Review
Materials Science, Multidisciplinary
Na Xu, Wenxin Xu, Manyue Zhang, Jia Yu, Guixia Ling, Peng Zhang
Summary: The traditional way of disease diagnosis faces issues such as wound infection and pain. Minimally invasive detection of biomarkers, using microneedles (MNs) to collect interstitial fluid (ISF) from the skin, has gained attention as a new method for patient monitoring and disease diagnosis. The advantages of MNs, including painless collection and patient compliance, open up new possibilities for individualized and long-term treatments.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Physiology
Yoshiyuki Akiyama, Jian-Rong Yao, Karl J. Kreder, Michael A. O'Donnell, Susan K. Lutgendorf, Dan Lyu, Daichi Maeda, Haruki Kume, Yukio Homma, Yi Luo
Summary: This study established a novel animal model for Hunner-type interstitial cystitis (HIC) using a transgenic mouse model (URO-OVA) through autoimmunity to the bladder urothelium. The model reproduced histological and clinical features of human HIC, providing a valuable tool for HIC research.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Hee Seo Son, Hana Yoon, Hye Sun Lee, Jang Hwan Kim
Summary: Adding hydrodistension (HD) to transurethral fulguration (TUF) tends to be more effective in controlling pain in Hunner-type IC/BPS compared to TUF alone, indicating the potential role of normal-appearing background areas in the pain of IC/BPS.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Kwang Jin Ko, Michael Jakun Koo, Seokhwan Bang, Hye Jin Byun, Min-Ji Kim, Kyunga Kim, Kyu-Sung Lee
Summary: This study compared the outcomes of transurethral ablation plus postoperative instillation of hyaluronic acid and chondroitin sulfate (HACS group) with transurethral ablation only in patients with Hunner type interstitial cystitis. The results showed that intravesical instillation of hyaluronic acid and chondroitin sulfate significantly reduced the recurrence rate and maintained symptom improvement for more than 1 year in patients with Hunner type interstitial cystitis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Yoshiyuki Akiyama, Kaori Harada, Jimpei Miyakawa, Karl J. Kreder, Michael A. O'Donnell, Maeda Daichi, Hiroto Katoh, Miyuki Hori, Kensuke Owari, Kazunobu Futami, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yi Luo
Summary: This study reveals the unique cellular and immunological factors involved in HIC, including T helper 1/17+polarized immune responses, overexpression of IFN-gamma, enhanced cGAS-STING cytosolic DNA sensing pathway, and increased plasma cell infiltration in the bladder. The researchers also developed an anti-IFN-gamma DNA aptamer that significantly ameliorated bladder inflammation, pelvic pain, and voiding dysfunction in a murine HIC model.
Review
Chemistry, Multidisciplinary
Vundrala Sumedha Reddy, Bhawana Agarwal, Zhen Ye, Chuanqi Zhang, Kallol Roy, Amutha Chinnappan, Roger J. Narayan, Seeram Ramakrishna, Rituparna Ghosh
Summary: Biosensors have the potential to revolutionize the biomedical field due to their portability, cost-effectiveness, and ease of operation. Diabetes mellitus, a common condition leading to deaths worldwide, can be detected using biosensors in various biological fluids such as blood, urine, and sweat. This literature review provides an update on recent advances in biofluid-based sensors for glucose level detection.
Article
Engineering, Environmental
Hui Huang, Moyuan Qu, Yan Zhou, Wei Cao, Xiaohui Huang, Jian Sun, Wujin Sun, Xingwu Zhou, Meimei Xu, Xing Jiang
Summary: This study designed a microneedle patch for rapid and minimally invasive extraction of interstitial fluid (ISF) for breast cancer patients. By measuring tumor markers, the patch could detect cancer earlier than other common screening methods, leading to timely treatment and prolonged survival.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Xing Dong, Biao Ma, Lanjie Lei, Yichen Chen, Chengtao Xu, Chao Zhao, Hong Liu
Summary: This article reports the fabrication of three-dimensional (3D) NC material for minimally invasive bioassays in tumor interstitial fluid. The material showed enough mechanical strength and biocompatibility for penetration into mouse skin, and the highly ordered photonic structure on the surface greatly improved the sensitivity for fluorescence immunoassay of trace biomarkers. The method was successfully used to quantitatively detect TNF-alpha in mouse TIF, demonstrating its potential for future cancer diagnostics and treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Medicine, General & Internal
Pedro Moreira, Pedro Marilio Cardoso, Guilherme Macedo, Joao Santos-Antunes
Summary: Endoscopic submucosal dissection (ESD), endoscopic mucosal resection (EMR), and transanal minimally invasive surgery (TAMIS) are modern techniques that have significant roles in treating colorectal lesions. ESD allows for the resection of lesions of any size in a single piece, with advantages in oncological outcomes. EMR is a faster and accessible procedure but has limitations in en-bloc resection size. TAMIS is a minimally invasive surgical technique for rectal tumors, providing better visualization and minimal disruption. This article reviews the applications and evidence of these techniques in order to find the most suitable treatment for lesions in the rectum and anorectal junction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Sarah S. Al Ghamdi, Ira Leeds, Sandy Fang, Saowanee Ngamruengphong
Summary: Rectal cancer, accounting for one-third of colorectal cancer cases annually, can be prevented through early screening and appropriate management. Advances in diagnostic and therapeutic strategies have contributed to improved patient outcomes. This review summarizes the available minimally invasive endoscopic and surgical management options for rectal neoplasia.
Article
Infectious Diseases
Edmond J. Feris, Liliana Encinales, Carlos Awad, Joel N. H. Stern, Inna Tabansky, Luis Jimenez-Alvarez, Gustavo Ramirez-Martinez, Alfredo Cruz-Lagunas, Karen Bobadilla, Eduardo Marquez, Julio Granados-Montiel, Tatiana S. Rodriguez-Reyna, Marcelo Fernandez-Vina, Julio Granados, Joaquin Zuniga, Edmond J. Yunis
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2016)
Review
Psychiatry
Souhel Najjar, Silky Pahlajani, Virginia De Sanctis, Joel N. H. Stern, Amanda Najjar, Derek Chong
FRONTIERS IN PSYCHIATRY
(2017)
Article
Biochemistry & Molecular Biology
Inna Tabansky, Derin B. Keskin, Deepika Watts, Cathleen Petzold, Michael Funaro, Warren Sands, Paul Wright, Edmond J. Yunis, Souhel Najjar, Betty Diamond, Yonghao Cao, David Mooney, Karsten Kretschmer, Joel N. H. Stern
MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Inna Tabansky, Yupu Liang, Maya Frankfurt, Martin A. Daniels, Matthew Harrigan, Sarah Stern, Teresa A. Milner, Rebecca Leshan, Rrezarta Rama, Tabea Moll, Jeffrey M. Friedman, Joel N. H. Stern, Donald W. Pfaff
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Rheumatology
Simone Mader, Venkatesh Jeganathan, Yoshiyuki Arinuma, Yuichiro Fujieda, Irena Dujmovic, Jelena Drulovic, Yuka Shimizu, Yuko Sakuma, Joel N. H. Stern, Cynthia Aranow, Meggan Mackay, Shinsuke Yasuda, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond
ARTHRITIS & RHEUMATOLOGY
(2018)
Editorial Material
Urology & Nephrology
Alan J. Wein
JOURNAL OF UROLOGY
(2019)
Article
Education & Educational Research
Marie Cavuoto Petrizzo, Maria-Louise Barilla-LaBarca, Youn Seon Lim, Artemio M. Jongco, Michael Cassara, James Anglim, Joel N. H. Stern
BMC MEDICAL EDUCATION
(2019)
Review
Clinical Neurology
Claire Valburg, Anup Sonti, Joel N. H. Stern, Souhel Najjar, Asaff Harel
Summary: While there is limited data on specific diets in multiple sclerosis, there is increasing evidence that certain dietary factors may influence the disease. Larger randomized clinical trials are needed to provide definitive information on dietary factors as a modifiable risk factor in MS.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Letter
Allergy
Marie Cavuoto Petrizzo, Doreen M. Olvet, Joel N. H. Stern
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)
Article
Biochemical Research Methods
R. Warren Sands, Inna Tabansky, Catia S. Verbeke, Derin Keskin, Samuel Michel, Joel Stern, David J. Mooney
BIOCONJUGATE CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Robert M. Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J. Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R. Rilo, Edmund J. Miller, Souhel Najjar, Inna Tabansky, Joel N. H. Stern
Summary: Interstitial cystitis/bladder pain syndrome patients with Hunner lesions (HL) show local inflammatory events and increased levels of immune cells. Urinary levels of different cytokines are also elevated in HL patients, indicating different disease processes compared to patients without HL.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Kevin Duh, Michael G. Funaro, William DeGouveia, Sonia Bahlani, Dominic Pappas, Souhel Najjar, Inna Tabansky, Robert Moldwin, Joel N. H. Stern
DISCOVERY MEDICINE
(2018)
Article
Education, Scientific Disciplines
Samara B. Ginzburg, Susan Deutsch, Jaclyn Bellissimo, David E. Elkowitz, Joel N. H. Stern, Robert Lucito
ADVANCES IN MEDICAL EDUCATION AND PRACTICE
(2018)
Article
Medicine, Research & Experimental
Michael Funaro, Mark Messina, Maya Shabbir, Paul Wright, Souhel Najjar, Inna Tabansky, Joel N. H. Stern
DISCOVERY MEDICINE
(2016)