Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Pharmacology & Pharmacy
Yuan-Hong Jiang, Jia-Fong Jhang, Teng-Yi Lin, Han-Chen Ho, Yung-Hsiang Hsu, Hann-Chorng Kuo
Summary: The study found that intravesical PRP injection is effective in relieving symptoms of IC/BPS patients, with slightly lower efficacy after a single high-dose PRP injection compared to four low-dose PRP injections. The addition of components and injection site did not significantly affect therapeutic outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Liping Xu, Xinwei Song, Qiaoding Dai, Tianrong Guan, Yan Zhang, Na Lin, Ji-an Wang
Summary: This case report highlights the efficacy of Belimumab in treating refractory Lupus Cystitis, with significant improvements in symptoms, urinary markers, and protein levels observed in the patient. No relapse of lupus cystitis or SLE activity occurred during the 10-month follow-up period, demonstrating positive outcomes with Belimumab treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo
Summary: Urine oxidative stress biomarkers and inflammatory cytokines play important roles in diagnosing and differentiating clinical subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS).
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand
Summary: The study showed that baclofen has dose-dependent inhibitory effects on bladder nociception in rats, regardless of inflammation treatment. Intrathecal administration of baclofen effectively suppressed visceromotor responses to bladder distension, and the GABA(B) receptor antagonist could antagonize the analgesic effects of baclofen.
Article
Clinical Neurology
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigates the role of corticotropin-releasing factor receptor type II (CRFR2) mechanisms in bladder hyperalgesia. The findings demonstrate the association between CRFR2-related mechanisms and bladder hypersensitivity, supporting the therapeutic value of these agents in the treatment of painful bladder disorders.
Article
Obstetrics & Gynecology
Amy M. Ivare, Aneta Obloza, Jonathan C. Goddard
Summary: Bladder pain syndrome (BPS) is often overlooked in pregnancy, despite being a common symptom. This article reviews the current evidence on the impact of BPS on pregnancy and the available options for diagnosis and management, aiming to improve patient experience and outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Neurosciences
Buffie Clodfelder-Miller, Timothy J. Ness, Jennifer J. DeBerry
Summary: This study successfully established a mouse model with similar characteristics of bladder pain syndromes through NBI induction, providing a tool for the study of painful bladder disorders.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Food Science & Technology
Wenshuang Li, Zhenming Zheng, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Paierhati Tayier, Yousheng Yao
Summary: This study found that in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), repeated intravesical instillations of Sapylin after botulinum toxin A (BoNT/A) injection can produce significantly better clinical outcomes than BoNT/A alone, with good safety.
Letter
Obstetrics & Gynecology
Jian-Ling Yeh, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Chen-Yu Chen, Shiang-Ru Lu, Shu-Yu Yang, Fu-Wen Liang, Jhi-Joung Wang, Chung-Han Ho, Pei-Chi Hsiao
Summary: This study utilized Taiwan's nationwide claims database to investigate the incidence and prevalence of work-related musculoskeletal disorders (WMSD) among physical therapists (PTs). The results showed that the risk of WMSD among PTs was positively correlated with the frequency of patients seeking rehabilitation service. Age and gender were identified as important risk factors for developing WMSD among PTs.
Article
Nutrition & Dietetics
Yao-Tsung Lin, Li-Kai Wang, Kuo-Chuan Hung, Chia-Yu Chang, Li-Ching Wu, Chung-Han Ho, Jen-Yin Chen
Summary: This study evaluated the prevalence and predictors of insufficient plasma vitamin C among adults in a subtropical region. It found that male gender, high body mass index, age 20-39, and winter/spring were independent predictors of insufficient vitamin C. Subjects with insufficient vitamin C had lower high-density lipoprotein cholesterol levels and elevated levels of triglyceride, homocysteine, and hs-CRP. This highlights the public health issue of insufficient plasma vitamin C.
Article
Public, Environmental & Occupational Health
Ren-Long Jan, Chung-Han Ho, Jhi-Joung Wang, Yuh-Shin Chang
Summary: This study aimed to investigate the socio-demographic factors and systemic conditions associated with non-arteritic anterior ischaemic optic neuropathy (NAION). The findings showed that patients with diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension were more likely to develop NAION.
Review
Biochemistry & Molecular Biology
Yu-Chen Chen, Wei-Chia Lee, Yao-Chi Chuang
Summary: Urinary tract infections (UTIs) are common bacterial infections in healthcare settings, with a high rate of recurrence. Conventional antibiotic management may lead to multidrug-resistant uropathogens. Therefore, alternative non-antibiotic solutions targeting the pathogenicity of UTIs and inadequate host defenses are being explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Ju-Chuan Hu, Lin-Nei Hsu, Wei-Chia Lee, Yao-Chi Chuang, Hung-Jen Wang
Summary: This study aims to explore the safety and efficacy of BoNT-A injection in treating bladder and voiding dysfunction in PD and post-stroke patients. Currently, intradetrusor injection of BoNT-A is approved as a third-line therapy for nDO and idiopathic OAB by the FDA. However, the clinical use of BoNT-A for post-stroke patients is limited due to the development of urinary retention in about one-fifth of patients.
Article
Respiratory System
Kuang-Ming Liao, Jhi-Joung Wang, Chung-Han Ho
Summary: This study aimed to assess the long-term outcomes of COPD patients receiving triple therapy in real-world practice. The study found that over a 5-year observation period, COPD patients receiving triple therapy did not show a survival benefit compared to those not receiving triple therapy.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Oncology
Ching-Hu Wu, Chien-Wei Feng, Chiu-Lin Wang, Zhi-Hong Wen, Cheng-Yu Long, Feng-Hsiang Tang
Summary: Our data showed that cisplatin treatment induces production of reactive oxygen species (ROS) that regulate apoptotic protein expression and stimulate anti-oxidative signal, inhibiting cell migration. The intervention of Zfp90 enhanced apoptosis pathway and inhibited migrative pathway, thus regulating the sensitivity of ovarian cancer cells to cisplatin. This study suggests that loss of Zfp90 function promotes cisplatin sensitization in ovarian cancer cells through the regulation of Nrf2/HO-1 pathway, enhancing cell apoptosis and inhibiting migration.
Article
Biochemistry & Molecular Biology
Zong-Sheng Wu, Hou-Lun Luo, Yao-Chi Chuang, Wei-Chia Lee, Hung-Jen Wang, Michael B. Chancellor
Summary: Platelet-rich plasma (PRP) has been shown to alleviate symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS) by regulating inflammatory processes and promoting tissue repair. This study found that PRP could protect the urothelium during ischemia/hypoxia by decreasing apoptosis through modulating the expression of HIF1 alpha, the mitochondria-mediated intrinsic apoptotic pathway, and reducing ROS.
Article
Clinical Neurology
Ching-Hu Wu, Kun-Ling Lin, Cheng-Yu Long, Chien-Wei Feng
Summary: Parkinson's disease is a highly influential disease worldwide, and current medications only provide relief for symptoms without slowing down disease progression. However, the plant-derived compound isotetrandrine (ITD) has been found to possess neuroprotective activity both in vitro and in vivo. ITD inhibits inflammatory-related protein and mRNA expression, improves locomotor deficiency, and reduces apoptosis in zebrafish models of PD. The neuroprotective effects of ITD may be mediated through anti-neuroinflammation and antiapoptosis pathways involving PI3K, ERK, and HO-1.
PARKINSONS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Chia-Hung Tsai, Nan-Yao Lee, Chien-Ming Chao, Chi-Chung Chen, Chih-Cheng Lai, Chung-Han Ho, Yu-Chin Chen, Po-Yu Chen, Hung-Jen Tang, Hung-Jui Chen, Bo-An Su, Hsin-Yu Lai, Julie Chi Chow, Tu-Hsuan Chang
Summary: This study investigated the characteristics of blaNDM-producing Enterobacterales in southern Taiwan, revealing an increase in blaNDM-5 and blaOXA-181 co-harboring strains, particularly the dissemination of E. coli ST8346. These strains exhibited high-level resistance to carbapenems and aminoglycosides, and a distinct IncF plasmid encoding blaNDM-5 was identified.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Chung-Shu Lee, Chung-Han Ho, Kuang-Ming Liao, Yu-Cih Wu, Chin-Chung Shu
Summary: This study investigated the impact of standard treatment durations and adherence to anti-tuberculous therapy on recurrence after successful completion of tuberculosis treatment. The results showed that treatment duration did not affect recurrence, but incomplete adherence to standard therapy increased the risk of recurrence.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Chia-Hung Tsai, Yu-Chin Chen, Po-Yu Chen, Chih-Cheng Lai, Hung-Jen Tang, Yin-Ching Chuang, Chi-Chung Chen, Chung-Han Ho, Wei-Yun Hsu, Tu-Hsuan Chang
Summary: This study investigated the antibiotic susceptibility of Escherichia coli isolates in patients diagnosed with intra-abdominal infections in the Asia-Pacific region. The results showed that community-associated E. coli isolates generally had higher susceptibility rates for most antibiotics compared to hospital-associated isolates. Ceftriaxone and piperacillin/tazobactam exhibited reduced susceptibility rates in certain countries.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Cheng-Yu Long, Zi-Xi Loo, Ching-Hu Wu, Kun-Ling Lin, Chang-Lin Yeh, Chien-Wei Feng, Pei-Chi Wu
Summary: This study aimed to evaluate the correlation between the overall rest-stress distance measured by transperineal ultrasound (TPUS) and Q-tip test angle in women with urodynamic stress incontinence (USI), and determine the optimal cut-off value for predicting urethral hypermobility (UH). The results showed a strong correlation between the overall rest-stress distance in TPUS and Q-tip test angle, and a rest-stress distance of more than 13.3 mm was found to be an optimal cut-off value for predicting UH in women with USI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zong-Sheng Wu, Hung-Jen Wang, Wei-Chia Lee, Hou Lun Luo, Tsu-Kung Lin, Yao-Chi Chuang
Summary: Low-energy shock wave (LESW) treatment has therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and this study investigated its mechanism of action. In a rat model of carrageenan-induced prostatitis, LESW treatment suppressed prostatic pain, inflammatory reaction, and expression of sensory molecules. These findings suggest a link between the neuroinflammatory effects of LESW in CP/CPPS and imbalances in mitochondrial dynamics in the prostate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)