JNK Signaling in Stem Cell Self-Renewal and Differentiation

Targeting JNK pathway promotes human hematopoietic stem cell expansion

(2019) Xiong Xiao et al.   Cell Discovery

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells

(2019) Lili Du et al.   ACS Chemical Biology

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

(2019) Qing V. Li et al.   NATURE GENETICS

Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine

(2019) Juliane Mundorf et al.   Cell Reports

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

(2018) Rumela Chakrabarti et al.   SCIENCE

Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)

(2018) Shijian Zhang et al.   Oncology Letters

The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

(2018) Nomeda Girnius et al.   eLife

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

(2018) Adekunle Ebenezer Omole et al.   PeerJ

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

(2018) Jacob Insua‐Rodríguez et al.   EMBO Molecular Medicine

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

(2017) Dimakatso Alice Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis

(2017) C-Y Zhang et al.   LEUKEMIA

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

(2017) Tuomas Tammela et al.   NATURE

Interspecies organogenesis generates autologous functional islets

(2017) Tomoyuki Yamaguchi et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

Stem Cells: A Renaissance in Human Biology Research

(2016) Jun Wu et al.   CELL

Clinical Trials with Mesenchymal Stem Cells: An Update

(2016) Tiziana Squillaro et al.   CELL TRANSPLANTATION

Intestinal stem cell response to injury: lessons from Drosophila

(2016) Huaqi Jiang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway

(2016) Y Shen et al.   LEUKEMIA

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

(2016) X Xie et al.   ONCOGENE

JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells

(2016) Irina Neganova et al.   STEM CELLS

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

(2016) Ryo Sato et al.   STEM CELLS

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma

(2016) Myoung Sook Han et al.   Cell Reports

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Targeting the K-Ras - JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation

(2015) Masashi Okada et al.   Oncotarget

Regulatory Role of the JNK-STAT1/3 Signaling in Neuronal Differentiation of Cultured Mouse Embryonic Stem Cells

(2014) Zheng Zachory Wei et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells

(2014) MAN LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Switch From Canonical to Noncanonical Wnt Signaling Mediates Early Differentiation of Human Neural Stem Cells

(2014) Nora Bengoa-Vergniory et al.   STEM CELLS

Wnt signaling in adult intestinal stem cells and cancer

(2013) Michaela Krausova et al.   CELLULAR SIGNALLING

Vascular Progenitors From Cord Blood–Derived Induced Pluripotent Stem Cells Possess Augmented Capacity for Regenerating Ischemic Retinal Vasculature

(2013) Tea Soon Park et al.   CIRCULATION

Depletion of JARID1B induces cellular senescence in human colorectal cancer

(2013) KATSUYA OHTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

(2013) Ke Yao et al.   Stem Cell Research

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation

(2012) Yijing Li et al.   Molecular Cancer

Embryonic Stem Cell Markers

(2012) Wenxiu Zhao et al.   MOLECULES

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

(2012) Ken-ichiro Matsuda et al.   Scientific Reports

Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell Migration

(2011) Tamer S. Kaoud et al.   ACS Chemical Biology

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Cancer Stem Cell Niche: The Place to Be

(2011) T. Borovski et al.   CANCER RESEARCH

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

(2011) C. Cellurale et al.   MOLECULAR AND CELLULAR BIOLOGY

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

(2011) Daniel Schramek et al.   NATURE GENETICS

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

Distinct roles of JNK-1 and ERK-2 isoforms in permeability barrier repair and wound healing

(2010) Kathrin Koehler et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

c-Jun NH2-Terminal Kinase Is Required for Lineage-Specific Differentiation but Not Stem Cell Self-Renewal

(2010) P. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells

(2009) S C Kirkland   BRITISH JOURNAL OF CANCER

Phosphoproteomic Analysis of Human Embryonic Stem Cells

(2009) Laurence M. Brill et al.   Cell Stem Cell

Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

(2009) T. Tanei et al.   CLINICAL CANCER RESEARCH

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

(2009) Rocio Sancho et al.   EMBO JOURNAL

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species

(2009) J -J Lee et al.   ONCOGENE

Modeling early retinal development with human embryonic and induced pluripotent stem cells

(2009) J. S. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer

(2008) C. Odoux et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin

(2008) Zhi Huang et al.   CELLULAR SIGNALLING

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas

(2008) Jian Yi Li et al.   JOURNAL OF NEURO-ONCOLOGY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Origin of Stem Cells in Organogenesis

(2008) J. M. W. Slack   SCIENCE