Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway

Genetic and epigenetic heterogeneity in acute myeloid leukemia

(2016) Sheng Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

c-Jun NH 2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study

(2016) Mostafa Hussein et al.   FERTILITY AND STERILITY

Kruppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

(2016) K. Filarsky et al.   HAEMATOLOGICA

Kruppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

(2016) K. Filarsky et al.   HAEMATOLOGICA

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

(2015) Wei Li et al.   Molecular Cancer

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

(2015) Jessica Nordlund et al.   Clinical Epigenetics

miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias

(2014) Deepti Malik et al.   Molecular Cancer

Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis

(2014) Wen-Ting Yang et al.   PLoS One

Krüppel Like Factor 4 Promoter Undergoes Active Demethylation during Monocyte/Macrophage Differentiation

(2014) Manjula Karpurapu et al.   PLoS One

The Synergistic Repressive Effect of NF-κB and JNK Inhibitor on the Clonogenic Capacity of Jurkat Leukemia Cells

(2014) Xinli Liu et al.   PLoS One

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

(2013) P. Van Vlierberghe et al.   BLOOD

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Kruppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma

(2013) M. Schoenhals et al.   HAEMATOLOGICA

Expression of KLF4 is a predictive marker for survival in pediatric Burkitt lymphoma

(2013) Alberto Valencia-Hipόlito et al.   LEUKEMIA & LYMPHOMA

Promoter DNA Methylation Pattern Identifies Prognostic Subgroups in Childhood T-Cell Acute Lymphoblastic Leukemia

(2013) Magnus Borssén et al.   PLoS One

The roles of ATF2 (activating transcription factor 2) in tumorigenesis

(2012) Malgorzata Gozdecka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples

(2012) Xiaoping Guo et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

(2012) Katrin Faber et al.   JOURNAL OF CLINICAL INVESTIGATION

Krüppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen

(2012) Chun Shik Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Cytosolic Protein G0S2 Maintains Quiescence in Hematopoietic Stem Cells

(2012) Takeshi Yamada et al.   PLoS One

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

The bottleneck of JNK signaling: Molecular and functional characteristics of MKK4 and MKK7

(2011) Wiebke Haeusgen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

(2011) F Yu et al.   ONCOGENE

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma

(2010) H. Guan et al.   BLOOD

Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression

(2010) Peilin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Expression of the Transcription Factor E74-Like Factor 4 Is Regulated by the Mammalian Target of Rapamycin Pathway in CD8+ T Cells

(2010) T. Yamada et al.   JOURNAL OF IMMUNOLOGY

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

(2009) H. Kang et al.   BLOOD

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

(2009) Richard H. Ko et al.   JOURNAL OF CLINICAL ONCOLOGY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells

(2009) J. Cui et al.   MOLECULAR CANCER THERAPEUTICS

Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2

(2009) Takeshi Yamada et al.   NATURE IMMUNOLOGY

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

(2008) D. Wei et al.   CANCER RESEARCH

Dynamic regulation ofc-Myc proto-oncogene expression during lymphocyte development revealed by aGFP-c-Myc knock-in mouse

(2008) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET