Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy

T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease

(2020) Gregory P. Williams et al.   ACTA NEUROPATHOLOGICA

Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy

(2020) Micaela Johanna Glat et al.   JOURNAL OF NEURAL TRANSMISSION

Remyelination in multiple sclerosis

(2019) David Kremer et al.   CURRENT OPINION IN NEUROLOGY

Safety and preliminary efficacy of intranasal insulin for cognitive impairment in Parkinson disease and multiple system atrophy: A double-blinded placebo-controlled pilot study

(2019) Peter Novak et al.   PLoS One

Insulin and Autophagy in Neurodegeneration

(2019) Natália Prudente de Mello et al.   Frontiers in Neuroscience

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

(2019) Johannes Levin et al.   LANCET NEUROLOGY

FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models

(2019) Guadalupe Vidal-Martinez et al.   EXPERIMENTAL NEUROLOGY

FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures

(2019) Javier Vargas-Medrano et al.   NEUROPHARMACOLOGY

Association between serum uric acid level and multiple system atrophy: A meta-analysis

(2018) Xi Zhang et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Efficacy of Parenteral Amantadine Therapy in the Treatment of Multiple System Atrophy With Predominant Parkinsonism

(2018) Adit Friedberg et al.   CLINICAL NEUROPHARMACOLOGY

Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study

(2018) Xinxin Huang et al.   PARKINSONISM & RELATED DISORDERS

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

(2018) Fumiko Kusunoki Nakamoto et al.   Scientific Reports

Oligodendroglial A‐synucleinopathy driven neuroinflammation in multiple system atrophy

(2018) Alana Hoffmann et al.   BRAIN PATHOLOGY

Synergistic Pressor Effect of Atomoxetine and Pyridostigmine in Patients With Neurogenic Orthostatic Hypotension

(2018) Luis E. Okamoto et al.   HYPERTENSION

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

(2018) Antonio Heras-Garvin et al.   MOVEMENT DISORDERS

Up-regulation of protective neuronal MicroRNAs by FTY720 and novel FTY720-derivatives

(2018) Javier Vargas-Medrano et al.   NEUROSCIENCE LETTERS

Insulin deficiency: A possible link between obesity and cognitive function

(2017) Ghazaleh Nameni et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

(2017) Tomasz Brudek et al.   Molecular Neurodegeneration

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

(2017) Hien Tran Zhao et al.   Molecular Therapy-Nucleic Acids

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

(2017) David I. Finkelstein et al.   Acta Neuropathologica Communications

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

(2017) Elvira Valera et al.   Acta Neuropathologica Communications

α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy

(2016) Benjamin Ettle et al.   ACTA NEUROPATHOLOGICA

Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder

(2016) Hyun Jung Park et al.   ACTA NEUROPATHOLOGICA

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum

(2016) Emanuele Barca et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A genome-wide association study in multiple system atrophy

(2016) Anna Sailer et al.   NEUROLOGY

Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease

(2016) Fábio G. Teixeira et al.   Stem Cells Translational Medicine

Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study

(2015) Lisette Salvesen et al.   CEREBRAL CORTEX

Association of serum uric acid level with cognitive function among patients with multiple system atrophy

(2015) Bei Cao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Natural history of multiple system atrophy in the USA: a prospective cohort study

(2015) Phillip A Low et al.   LANCET NEUROLOGY

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

(2015) Rowan Radford et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation

(2015) Aoife P. Kiely et al.   Molecular Neurodegeneration

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

(2015) Markus Mandler et al.   Molecular Neurodegeneration

Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy — A stereological study

(2015) Lisette Salvesen et al.   NEUROBIOLOGY OF DISEASE

Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration

(2015) Keiko Nakamura et al.   NEUROPATHOLOGY

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

(2015) Bruno Di Marco Vieira et al.   Frontiers in Cellular Neuroscience

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

(2015) Mehdi Djelloul et al.   Stem Cell Reports

Efficacy of Atomoxetine Versus Midodrine for the Treatment of Orthostatic Hypotension in Autonomic Failure

(2014) Claudia E. Ramirez et al.   HYPERTENSION

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

(2014) Verena E.L. May et al.   NEUROBIOLOGY OF AGING

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

(2014) Javier Vargas-Medrano et al.   ACS Medicinal Chemistry Letters

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Consensus Paper: Management of Degenerative Cerebellar Disorders

(2013) W. Ilg et al.   CEREBELLUM

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

The natural history of multiple system atrophy: a prospective European cohort study

(2013) Gregor K Wenning et al.   LANCET NEUROLOGY

Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

From Blood to the Brain: Can Systemically Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier?

(2013) Linan Liu et al.   Stem Cells International

A randomized trial of mesenchymal stem cells in multiple system atrophy

(2012) Phil Hyu Lee et al.   ANNALS OF NEUROLOGY

Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and Parkinson's Disease

(2012) Zeshan Ahmed et al.   BRAIN PATHOLOGY

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Neuropathology underlying clinical variability in patients with synucleinopathies

(2011) Glenda M. Halliday et al.   ACTA NEUROPATHOLOGICA

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

The neuropathology, pathophysiology and genetics of multiple system atrophy

(2011) Z. Ahmed et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model

(2011) Nadia Stefanova et al.   NEUROTOXICITY RESEARCH

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

(2010) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

Neuroprotective Effect of Human Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy Parkinsonism

(2010) Hyun-Jung Park et al.   CELL TRANSPLANTATION

The phenotype spectrum of Japanese multiple system atrophy

(2010) T. Ozawa et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Presentation, diagnosis, and management of multiple system atrophy in Europe: Final analysis of the European multiple system atrophy registry

(2010) Martin Köllensperger et al.   MOVEMENT DISORDERS

Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy☆

(2010) Takafumi Hasegawa et al.   NEUROCHEMISTRY INTERNATIONAL

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNCAvariants are associated with increased risk for multiple system atrophy

(2009) Sonja W. Scholz et al.   ANNALS OF NEUROLOGY

Reply to: SNCA variants are associated with increased risk of multiple system atrophy

(2009) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy

(2009) Ammar Al-Chalabi et al.   PLoS One

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action

(2008) You-Joung Kim et al.   GLIA

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY

Glial cytoplasmic inclusions and tissue injury in multiple system atrophy: A quantitative study in white matter (olivopontocerebellar system) and gray matter (nigrostriatal system)

(2008) Keisuke Ishizawa et al.   NEUROPATHOLOGY