Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7
出版年份 2020 全文链接
标题
Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 6, Pages 2132
出版商
MDPI AG
发表日期
2020-03-20
DOI
10.3390/ijms21062132
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
- (2019) Pascal Häfliger et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways
- (2018) Michelle van Geldermalsen et al. BMC CANCER
- Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
- (2018) Rajesh K. Singh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural properties for selective and efficient l -type amino acid transporter 1 (LAT1) mediated cellular uptake
- (2018) Jussi Kärkkäinen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)
- (2018) Huan-Chieh Chien et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
- (2018) Natesh Singh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs
- (2017) Elena Puris et al. JOURNAL OF CONTROLLED RELEASE
- A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
- (2017) Rakesh K. Pathak et al. MOLECULAR CANCER THERAPEUTICS
- Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
- (2017) Keitaro Hayashi et al. World Journal of Gastrointestinal Oncology
- Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling
- (2016) Shushi Nagamori et al. AMINO ACIDS
- LAT-1 activity of meta -substituted phenylalanine and tyrosine analogs
- (2016) Evan Augustyn et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors
- (2016) Kristiina M. Huttunen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells
- (2016) Kristiina M. Huttunen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
- (2016) Mikko Gynther et al. MOLECULAR PHARMACEUTICS
- Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
- (2016) Mikko Gynther et al. NEUROCHEMICAL RESEARCH
- Aspartate-modified doxorubicin on itsN-terminal increases drug accumulation inLAT1-overexpressing tumors
- (2015) Weidang Wu et al. CANCER SCIENCE
- Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1)
- (2015) Jarkko Rautio et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Quantitative Insight into the Design of Compounds Recognized by theL-Type Amino Acid Transporter 1 (LAT1)
- (2014) Henna Ylikangas et al. ChemMedChem
- Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer
- (2013) Kyoichi Kaira et al. BMC CANCER
- A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers
- (2013) Melissa Millard et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cancer preventive effect of Thai rat-tailed radish (Raphanus sativus L. var. caudatus Alef)
- (2013) Piman Pocasap et al. Journal of Functional Foods
- Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion
- (2012) Henna Ylikangas et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery
- (2011) Lauri Peura et al. MOLECULAR PHARMACEUTICS
- l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- (2009) Koji Oda et al. CANCER SCIENCE
- BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells
- (2008) Chun Sung Kim et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
- (2008) Eva M. del Amo et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Prodrugs: design and clinical applications
- (2008) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started