The GPR17 Receptor—A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis

The emergence of follow-on disease-modifying therapies for multiple sclerosis

(2019) Brandon P Moss et al.   Multiple Sclerosis Journal

Orphan G protein-coupled receptors: The role in CNS disorders

(2018) Mohaddeseh Sadat Alavi et al.   BIOMEDICINE & PHARMACOTHERAPY

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors

(2018) Thomas Pleli et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

(2018) Alan J Thompson et al.   LANCET NEUROLOGY

G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination

(2018) Changqing Lu et al.   Scientific Reports

Biomarkers in Multiple Sclerosis

(2018) Anu Paul et al.   Cold Spring Harbor Perspectives in Medicine

GPR17 mediates ischemia-like neuronal injury via microglial activation

(2018) Bing Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis

(2018) Angela Dziedzic et al.   Advances in Clinical and Experimental Medicine

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

(2017) Crystal Leung et al.   MOLECULES

Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors

(2017) Muhammad Zahid Khan et al.   PSYCHOPHARMACOLOGY

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

(2017) Piotr Lewczuk et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Visualizing the GPCR Network: Classification and Evolution

(2017) Geng-Ming Hu et al.   Scientific Reports

Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries

(2017) Rahul Raj et al.   PLOS MEDICINE

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression

(2017) Liesbet M. Peeters et al.   Frontiers in Immunology

The environment rules: spatiotemporal regulation of oligodendrocyte differentiation

(2016) Sonia R Mayoral et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications

(2016) Giordani Rodrigues Dos Passos et al.   MEDIATORS OF INFLAMMATION

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Intertwining extracellular nucleotides and their receptors with Ca2+in determining adult neural stem cell survival, proliferation and final fate

(2016) Davide Lecca et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Disease modifying therapies for relapsing multiple sclerosis

(2016) Dean M Wingerchuk et al.   BMJ-British Medical Journal

Disease modifying therapies for relapsing multiple sclerosis

(2016) Dean M Wingerchuk et al.   BMJ-British Medical Journal

Gq-Coupled Receptors in Autoimmunity

(2016) Lu Zhang et al.   Journal of Immunology Research

Symptomatic management in multiple sclerosis

(2015) Pushkar Shah   Annals of Indian Academy of Neurology

Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

(2015) Vijitha K. Senanayake et al.   BMC Neurology

IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis

(2015) Carlos A. Arbelaez et al.   JOURNAL OF IMMUNOLOGY

Multiple Sclerosis and T Lymphocytes: An Entangled Story

(2015) Laurine Legroux et al.   Journal of Neuroimmune Pharmacology

Olig1 Function Is Required for Oligodendrocyte Differentiation in the Mouse Brain

(2015) J. Dai et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

(2015) Benjamin Ettle et al.   MOLECULAR NEUROBIOLOGY

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

Biomarkers of Inflammation and Axonal Degeneration/Damage in Patients with Newly Diagnosed Multiple Sclerosis: Contributions of the Soluble CD163 CSF/Serum Ratio to a Biomarker Panel

(2015) Morten Stilund et al.   PLoS One

Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells

(2014) Khrishen Cunnusamy et al.   CLINICAL IMMUNOLOGY

Relapsing and progressive forms of multiple sclerosis

(2014) Ranjan Dutta et al.   CURRENT OPINION IN NEUROLOGY

The diagnosis of multiple sclerosis and the various related demyelinating syndromes: A critical review

(2014) Dimitrios Karussis   JOURNAL OF AUTOIMMUNITY

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

(2014) Olga Ciccarelli et al.   LANCET NEUROLOGY

Myelin--More than Insulation

(2014) R. D. Fields   SCIENCE

Relevance of rhodopsin studies for GPCR activation

(2013) Xavier Deupi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pathology and disease mechanisms in different stages of multiple sclerosis

(2013) Hans Lassmann   JOURNAL OF THE NEUROLOGICAL SCIENCES

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

(2013) Heike Franke et al.   Purinergic Signalling

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

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The socioeconomic consequences of multiple sclerosis: A controlled national study

(2011) Poul Jennum et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Regulation of remyelination in multiple sclerosis

(2011) Khalid A. Hanafy et al.   FEBS LETTERS

Olig1 is expressed in human oligodendrocytes during maturation and regeneration

(2011) Ahmad Othman et al.   GLIA

Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury

(2011) Christiane Simon et al.   GLIA

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cells of the oligodendroglial lineage, myelination, and remyelination

(2010) Veronique E. Miron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

(2010) T Benned-Jensen et al.   BRITISH JOURNAL OF PHARMACOLOGY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death

(2010) Stefania Ceruti et al.   GLIA

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Regulation of RhoGEF proteins by G12/13-coupled receptors

(2009) Sandra Siehler   BRITISH JOURNAL OF PHARMACOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelination

(2009) K. Kucharova et al.   NEUROSCIENCE

Functions and Regulatory Mechanisms of Gq-Signaling Pathways

(2009) Norikazu Mizuno et al.   NEUROSIGNALS

Oligodendrocyte development and the onset of myelination in the human fetal brain

(2009) Igor Jakovcevski   Frontiers in Neuroanatomy

The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

(2008) Denis J. Dupré et al.   Annual Review of Pharmacology and Toxicology

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms underlying airway smooth muscle contraction and proliferation: Implications for asthma

(2008) Girolamo Pelaia et al.   RESPIRATORY MEDICINE

Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy

(2007) Diana T. McCloskey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

(2007) Simon Yona et al.   FASEB JOURNAL

LARG and mDia1 Link Gα12/13 to Cell Polarity and Microtubule Dynamics

(2007) Polyxeni Goulimari et al.   MOLECULAR BIOLOGY OF THE CELL